Evidence map›Paper›PMID 30561419›Full record

ReviewActa bio-medica : Atenei Parmensis2018

Non-invasive tests for the diagnosis of helicobacter pylori: state of the art.

Stefano Kayali, Rosalia Aloe, Chiara Bonaguri, Federica Gaiani, Marco Manfredi, Gioacchino Leandro, Fabiola Fornaroli, Francesco Di Mario, Gian Luigi De' Angelis

Open access · greenAbstract readReview
In one paragraph

Review in Acta bio-medica : Atenei Parmensis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Social determinants of health andFrontiers in public health · 2025
    Pooled it
  2. Urea breath test forWorld journal of gastroenterology · 2024
    Pooled it
  3. Pooled it
  4. CurrentJGH open : an open access journal of gastroenterology and hepatology · 2026
    Review
  5. ActiveJournal of clinical medicine research · 2026
    Article
  6. CirculatingFrontiers in cellular and infection microbiology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Prevalence, Risk Factors, and Endoscopic Findings ofAntibiotics (Basel, Switzerland) · 2025
    Article
  11. Article
  12. Article
  13. Review of Methods for DetectionJGH open : an open access journal of gastroenterology and hepatology · 2025
    Review
  14. Article
  15. Selected Markers of Inflammation in the Saliva of Children Infected withInternational journal of molecular sciences · 2024
    Article
  16. Advances in Diagnostic Modalities forLife (Basel, Switzerland) · 2024
    Review
  17. Article
  18. Change in Diagnosis ofAntibiotics (Basel, Switzerland) · 2024
    Review
  19. Article
  20. SPR and Double Resonance LPG Biosensors forSensors (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Stefano KayaliGastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy. federica.gaiani@studenti.unipr.it.
Rosalia Aloe
Chiara Bonaguri
Federica Gaiani
Marco Manfredi
Gioacchino Leandro
Fabiola Fornaroli
Francesco Di Mario
Gian Luigi De' Angelis
University of Parma · ITGastroenterology Hospital "Saverio de Bellis" · ITOspedale Sant'Anna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Usually, non-invasive tests are the first methods for diagnosing Helicobacter pylori (HP) infection. Among these, serological test, stool antigen research and urea breath test are the most used. Antibodies anti-HP are not recommended in low prevalence population, moreover they cannot reveal an ongoing infection, but they only prove a contact with the bacterium. Also, they can persist for a long time after the eradication of the infection, therefore, they should not be used to verify the success of eradication therapy. Stool antigen research and Urea Breath Test (UBT) are useful both in diagnosis and during follow-up after eradication treatment. The stool antigen test is cheaper than Urea breath test with similar sensitivity and specificity.  Non-invasive tests are not able to diagnose the associated complications to HP infection.

Indexed as

Antibodies, BacterialAntigens, BacterialBreath TestsFecesFemaleHelicobacter InfectionsHelicobacter pyloriHumansImmunologic TestsMaleSensitivity and SpecificityUreaAntibodies, BacterialAntigens, BacterialUrea

Identifiers

PMID30561419
PMCPMC6502209
OpenAlexW2990865163

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.