SynthesiseLife2018
Aquaporin-4-dependent glymphatic solute transport in the rodent brain.
Registry-linked trialOpen access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06857136 (The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH), which is not on this map. Cited by 475 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
475citing papers in PubMed, 2 pooled it
22.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH
Who cites it
475 citing papers in PubMed, 2 syntheses or guidelines pooled it, 702 citations in OpenAlex.
- Glymphatic-related imaging findings in type 2 diabetes mellitus: a systematic review and exploratory meta-analysis of DTI-ALPS studies.Frontiers in aging neuroscience · 2026Pooled it
- Unveiling the glymphatic system's impact on neurodegenerative diseases: a comprehensive bibliometric analysis (2012-2024).Frontiers in aging neuroscience · 2025Pooled it
- The glymphatic system clears amyloid beta and tau from brain to plasma in humans.Nature communications · 2026Trial
- Trial
- Quantifying dilated perivascular spaces in children with sickle cell disease.Pediatric blood & cancer · 2024Trial
- Brain Clearance of Contrast Agent in Intravenous DCE-MRI Is Measurable and Cannot Be Explained by Clearance Across the BBB Alone.Magnetic resonance in medicine · 2026Article
- The glymphatic-lymphatic axis: known pathways, open questions, and emerging roles in neurodegeneration.Translational neurodegeneration · 2026Review
- Spatial organization of AQP4 water channel expression in the human brain.Science advances · 2026Article
- Albumin-binding dendrimer-conjugated siRNA enables safe and effective gene silencing throughout the central nervous system.Nucleic acids research · 2026Article
- Temporal transcriptomic remodeling after controlled cortical impact reveals delayed AQP4/SNTA1 expression imbalance associated with ion-homeostatic remodeling.bioRxiv : the preprint server for biology · 2026Article
- The Glymphatic System in Neurological Diseases: Mechanisms, Imaging Surrogates, and Translational Uncertainties.Current neurology and neuroscience reports · 2026Review
- Review
- Glymphatic system dysfunction: a link between sleep disorders and neurodegeneration.Psychopharmacology · 2026Review
- Brain clearance physiology in traumatic brain injury: From disruption to therapeutic potential.The Journal of physiology · 2026Article
- Central nervous system lymphatic network: from the maintenance of brain homeostasis to emerging therapeutic perspectives in neurodegenerative diseases.Translational neurodegeneration · 2026Review
- Novel Therapeutic Insights Into Alzheimer's Disease: Glymphatic System and Meningeal Lymphatic Vessels.Aging cell · 2026Review
- The Glymphatic System in α-Synucleinopathies.Yonsei medical journal · 2026Review
- Regulation and function of specialized membrane protrusions in intercellular communication.Nature reviews. Molecular cell biology · 2026Review
- Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels.Nature neuroscience · 2026Article
- Imaging Biomarkers of the Glymphatic System in the Developing Brain.Korean journal of radiology · 2026Review
415 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 10 institutions in 6 countries.
Humberto Mestre *Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States.ORCID https://orcid.org/0000-0001-5876-5397
Lauren M Hablitz *Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States.ORCID http://orcid.org/0000-0001-6159-7742
Anna Lr Xavier *Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Weixi Feng *Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China.
Wenyan Zou *Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China.
Tinglin Pu *Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China.
Hiromu Monai *RIKEN Center for Brain Science, Wako, Japan.ORCID https://orcid.org/0000-0002-6975-7218
Giridhar Murlidharan *Gene Therapy Center, The University of North Carolina, Chapel Hill, United States.
Ruth M Castellanos Rivera *Gene Therapy Center, The University of North Carolina, Chapel Hill, United States.
Matthew J Simon *Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, United States.
Martin M Pike *Advanced Imaging Research Center, Oregon Health and Science University, Portland, United States.
Virginia Plá *Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States.ORCID http://orcid.org/0000-0002-5501-0789
Ting Du *Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States.
Benjamin T Kress *Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States.
Xiaowen WangRIKEN Center for Brain Science, Wako, Japan.
Benjamin A PlogCenter for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States.
Alexander S ThraneCenter for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Iben LundgaardCenter for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States.
Yoichiro AbeDepartment of Pharmacology,School of Medicine, Keio University, Tokyo, Japan.ORCID http://orcid.org/0000-0001-6163-8794
Masato YasuiDepartment of Pharmacology,School of Medicine, Keio University, Tokyo, Japan.
John H ThomasDepartment of Mechanical Engineering, University of Rochester, Rochester, United States.
Ming XiaoJiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China.
Hajime HiraseRIKEN Center for Brain Science, Wako, Japan.ORCID http://orcid.org/0000-0003-3806-6905
Aravind AsokanGene Therapy Center, The University of North Carolina, Chapel Hill, United States.
Jeffrey J IliffDepartment of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, United States.
Maiken NedergaardCenter for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States.ORCID https://orcid.org/0000-0001-6502-6031
University of Rochester Medical Center · USNanjing Medical University · CNOregon Health & Science University · USUniversity of Copenhagen · DKUniversity of North Carolina at Chapel Hill · USKeio University · JPRIKEN Center for Brain Science · JPLund University · SEOchanomizu University · JPUniversity of Rochester · US
Funding
Determinants of AAV TropismR01HL089221 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Aravind Asokan · 2009 to 2026
$8.1MUltrastructure and Single Particle Microscopy CoreP30NS061800 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A · 2009 to 2020
$6.6MNRSA Training CoreTL1TR002244 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$4.6MPara-Vascular Basis of Small Vessel DiseaseR01NS100366 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2016 to 2020
$3.8MAge and AD related bottlenecks in glymphatic-lymphatic waste transportRF1AG057575 · NIA · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2017 to 2017
$3.2MCapillary hyperemia in white matter: Novel mechanistic insight and effect of hypertension and agingRF1NS110049 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN, WAN, JIANDI · 2018 to 2018
$2.9MCircRNAs and CNS Gene TransferR01NS099371 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ASOKAN, ARAVIND · 2017 to 2021
$1.9MDefining the role of age-related glymphatic pathway impairment in amyloid beta plaque depositionR01AG054456 · NIA · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI ILIFF, JEFFREY J · 2017 to 2021
$1.8MRole of perivascular aquaporin-4 polarization in post-traumatic neurodegenerationR01NS089709 · NINDS · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI ILIFF, JEFFREY J · 2015 to 2019
$1.7MGlymphatic function in a transgenic rat model of Alzheimer's diseaseR01AG048769 · NIA · UNIVERSITY OF ROCHESTER · PI BENVENISTE, HELENE D, NEDERGAARD, MAIKEN · 2014 to 2018
$1.4MChanges in Water Channel Localization to Astrocytic Endfeet with AgingF31AG054093 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI SIMON, MATTHEW · 2017 to 2018
$83kNCATS NIH HHS TL1 TR002244NHLBI NIH HHS R01 HL089221NIA NIH HHS F31 AG054093NIA NIH HHS R01 AG048769NIA NIH HHS R01 AG054456NIA NIH HHS RF1 AG057575NIA NIH HHS RF1 AG057575-01NIH HHS AG048769NIH HHS AG054456NIH HHS HL089221NIH HHS NS061800NIH HHS NS078394NIH HHS NS089709NIH HHS NS099371NIH HHS NS100366NINDS NIH HHS P30 NS061800NINDS NIH HHS R01 NS089709NINDS NIH HHS R01 NS099371NINDS NIH HHS R01 NS100366NINDS NIH HHS RF1 NS110049
Abstract
The glymphatic system is a brain-wide clearance pathway; its impairment contributes to the accumulation of amyloid-β. Influx of cerebrospinal fluid (CSF) depends upon the expression and perivascular localization of the astroglial water channel aquaporin-4 (AQP4). Prompted by a recent failure to find an effect of
Indexed as
Glymphatic SystemAnimalsAquaporin 4AstrocytesBiological TransportBrainCerebrospinal FluidExtracellular FluidMice, KnockoutRatsAquaporin 4aquaporin-4cerebrospinal fluidglymphaticmeta-analysismouseneurosciencereplication studysolute transport
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT06857136ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.