Evidence map›Paper›PMID 30561313›Full record

ArticleEmerging infectious diseases2019

Prescription of Antibacterial Drugs for HIV-Exposed, Uninfected Infants, Malawi, 2004-2010.

Alexander C Ewing, Nicole L Davis, Dumbani Kayira, Mina C Hosseinipour, Charles van der Horst, Denise J Jamieson, Athena P Kourtis, Breastfeeding, Antiretrovirals and Nutrition study team

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexander C Ewing
Nicole L Davis
Dumbani Kayira
Mina C Hosseinipour
Charles van der Horst
Denise J Jamieson
Athena P Kourtis
Breastfeeding, Antiretrovirals and Nutrition study team

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
UNC Center for Health Promotion and Disease PreventionU48DP000059 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AMMERMAN, ALICE S · 2004 to 2009
$14.4M
Carolina Population CenterR24HD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MORGAN, SAMUEL PHILIP · 2005 to 2014
$10.0M
AIDS INTERNATIONAL TRAINING AND RESEARCH PROGRAMD43TW001039 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ADIMORA, ADAORA A · 1998 to 2013
$9.9M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
ACL HHS U48DP001944FIC NIH HHS D43 TW001039FIC NIH HHS R24 TW007988NCCDPHP CDC HHS U48 DP000059NIAID NIH HHS P30 AI050410NICHD NIH HHS P2C HD050924NICHD NIH HHS R24 HD050924
6 · The paper itself

Abstract

Antimicrobial drug resistance is a serious health hazard driven by overuse. Administration of antimicrobial drugs to HIV-exposed, uninfected infants, a population that is growing and at high risk for infection, is poorly studied. We therefore analyzed factors associated with antibacterial drug administration to HIV-exposed, uninfected infants during their first year of life. Our study population was 2,152 HIV-exposed, uninfected infants enrolled in the Breastfeeding, Antiretrovirals and Nutrition study in Lilongwe, Malawi, during 2004-2010. All infants were breastfed through 28 weeks of age. Antibacterial drugs were prescribed frequently (to 80% of infants), and most (67%) of the 5,329 prescriptions were for respiratory indications. Most commonly prescribed were penicillins (43%) and sulfonamides (23%). Factors associated with lower hazard for antibacterial drug prescription included receipt of cotrimoxazole preventive therapy, receipt of antiretroviral drugs, and increased age. Thus, cotrimoxazole preventive therapy may lead to fewer prescriptions for antibacterial drugs for these infants.

Indexed as

Antimicrobial StewardshipAge FactorsAnti-Bacterial AgentsAntibiotic ProphylaxisAnti-Retroviral AgentsBreast FeedingDrug Resistance, BacterialFemaleHIVHumansInfantMalePenicillinsPovertyPregnancyPregnancy Complications, InfectiousAnti-Bacterial AgentsAnti-Retroviral AgentsPenicillinsSulfonamidesTrimethoprim, Sulfamethoxazole Drug Combinationantibacterialantibiotic prophylaxisantibiotic stewardshipantimicrobial resistancedrug resistanceHIV-1HIV/AIDSinfantinfectious disease medicineMalawipenicillinspovertytrimethoprim/sulfamethoxazole drug combination

Identifiers

PMID30561313
PMCPMC6302572
OpenAlexW2904116287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.