ArticleEmerging infectious diseases2018
Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential.
Article in Emerging infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- HA198 mutations in H9N2 avian influenza: molecular dynamics insights into receptor binding.Frontiers in veterinary science · 2024Article
- The emergence of new antigen branches of H9N2 avian influenza virus in China due to antigenic drift on hemagglutinin through antibody escape at immunodominant sites.Emerging microbes & infections · 2023Article
- Antigenic mapping of the hemagglutinin of the H9 subtype influenza A viruses using sera from Japanese quail (Journal of virology · 2023Article
- Amino Acid Variation at Hemagglutinin Position 193 Impacts the Properties of H9N2 Avian Influenza Virus.Journal of virology · 2023Article
- Deciphering the rule of antigen-antibody amino acid interaction.Frontiers in immunology · 2023Article
- Article
- Phylogenetic analysis, molecular changes, and adaptation to chickens of Mexican lineage H5N2 low-pathogenic avian influenza viruses from 1994 to 2019.Transboundary and emerging diseases · 2022Article
- Article
- Coinfection of Chickens with H9N2 and H7N9 Avian Influenza Viruses Leads to Emergence of Reassortant H9N9 Virus with Increased Fitness for Poultry and a Zoonotic Potential.Journal of virology · 2022Article
- Avian Influenza a H9N2 Viruses in Morocco, 2018-2019.Viruses · 2022Article
- Assessing the effects of a two-amino acid flexibility in the Hemagglutinin 220-loop receptor-binding domain on the fitness of Influenza A(H9N2) viruses.Emerging microbes & infections · 2021Article
- Identification of key residues involved in the neuraminidase antigenic variation of H9N2 influenza virus.Emerging microbes & infections · 2021Article
- Article
- SARS-CoV-2 one year on: evidence for ongoing viral adaptation.The Journal of general virology · 2021Review
- PA-X is an avian virulence factor in H9N2 avian influenza virus.The Journal of general virology · 2021Article
- Genetic determinants of receptor-binding preference and zoonotic potential of H9N2 avian influenza viruses.Journal of virology · 2021Article
- Adsorptive mutation and N-linked glycosylation modulate influenza virus antigenicity and fitness.Emerging microbes & infections · 2020Article
- L226Q Mutation on Influenza H7N9 Virus Hemagglutinin Increases Receptor-Binding Avidity and Leads to Biased Antigenicity Evaluation.Journal of virology · 2020Article
- Genetically and Antigenically Divergent Influenza A(H9N2) Viruses Exhibit Differential Replication and Transmission Phenotypes in Mammalian Models.Journal of virology · 2020Article
- Historical origins and zoonotic potential of avian influenza virus H9N2 in Tunisia revealed by Bayesian analysis and molecular characterization.Archives of virology · 2020Article
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
We characterized 55 influenza A(H9N2) viruses isolated in Pakistan during 2014-2016 and found that the hemagglutinin gene is of the G1 lineage and that internal genes have differentiated into a variety of novel genotypes. Some isolates had up to 4-fold reduction in hemagglutination inhibition titers compared with older viruses. Viruses with hemagglutinin A180T/V substitutions conveyed this antigenic diversity and also caused up to 3,500-fold greater binding to avian-like and >20-fold greater binding to human-like sialic acid receptor analogs. This enhanced binding avidity led to reduced virus replication in primary and continuous cell culture. We confirmed that altered receptor-binding avidity of H9N2 viruses, including enhanced binding to human-like receptors, results in antigenic variation in avian influenza viruses. Consequently, current vaccine formulations might not induce adequate protective immunity in poultry, and emergence of isolates with marked avidity for human-like receptors increases the zoonotic risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.