ArticleRadiology2019
Perinodular and Intranodular Radiomic Features on Lung CT Images Distinguish Adenocarcinomas from Granulomas.
Abstract read
In one paragraph
Article in Radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 208 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
208citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
208 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Predictive value of radiomics for intracranial aneurysm rupture: a systematic review and meta-analysis.Frontiers in neuroscience · 2024Pooled it
- Integrated imaging and molecular analysis to decipher tumor microenvironment in the era of immunotherapy.Seminars in cancer biology · 2022Pooled it
- Radiomics based on enhanced CT for differentiating between pulmonary tuberculosis and pulmonary adenocarcinoma presenting as solid nodules or masses.Journal of cancer research and clinical oncology · 2023Trial
- Classification of Histological Types and Stages in Non-small Cell Lung Cancer Using Radiomic Features Based on CT Images.Journal of digital imaging · 2023Trial
- Spectral CT-based radiomics signature for distinguishing malignant pulmonary nodules from benign.BMC cancer · 2023Trial
- Peritumoral radiomics features on preoperative thin-slice CT images can predict the spread through air spaces of lung adenocarcinoma.Scientific reports · 2022Trial
- Development and validation of a preoperative CT-based radiomic nomogram to predict pathology invasiveness in patients with a solitary pulmonary nodule: a machine learning approach, multicenter, diagnostic study.European radiology · 2022Trial
- CT Densitometry and Morphology of Radiofrequency-Ablated Stage IA Non-Small Cell Lung Cancer: Results from the American College of Surgeons Oncology Group Z4033 (Alliance) Trial.Journal of vascular and interventional radiology : JVIR · 2020Trial
- Inter-Slice Representation Outweighs Bounding-Box Supervision Extent in Lightweight 2.5D Pulmonary Nodule Detection: A Whole-Volume Benchmark on LUNA16.Diagnostics (Basel, Switzerland) · 2026Article
- An interpretable biparametric MRI habitat radiomics model for predicting bone metastasis in prostate cancer: a dual-center study.Translational andrology and urology · 2026Article
- Multi-component radiological model based on intratumoral CT threshold segmentation for predicting visceral pleural invasion in lung adenocarcinoma ≤ 30 mm.Insights into imaging · 2026Article
- Preoperative prediction of visceral pleural invasion in clinical stage T1 invasive lung adenocarcinoma using intratumoral and peritumoral radiomics: a multicenter development, validation, and comparison study.BMC medical imaging · 2026Article
- Predicting response to neoadjuvant chemotherapy combined with immunotherapy in gastric cancer based on habitat imaging and peritumoral radiomics: a two-center study.Journal of translational medicine · 2026Article
- Radiomics in laryngeal squamous cell carcinoma: state of the art.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026Review
- Advancing lung adenocarcinoma diagnosis using peri-nodular features: a CT radiomics study for determining invasiveness in sub-centimeter pure ground glass nodules.Journal of thoracic disease · 2026Article
- Deep learning ensemble models for CT-based differentiation of malignant and benign sacral bone tumors: development and evaluation.Insights into imaging · 2026Article
- Computed tomography-based tumoral and peritumoral radiomics models for preoperative prediction of the spread through air spaces in patients with clinical stage I pure solid invasive lung adenocarcinoma: a multicenter study.Journal of thoracic disease · 2026Article
- The impact of AI on modern oncology from early detection to personalized cancer treatment.NPJ precision oncology · 2026Review
- Intranodular and perinodular radiomics features based on non-contrast CT to distinguish pulmonary cryptococcosis from lung adenocarcinoma: a two-center study.Frontiers in oncology · 2026Article
- Quantitative peri-lesional densitometry mapping via thin-slice volume rendering enhances differentiation of pneumonic-type lung cancer and inflammatory pneumonia.Frontiers in oncology · 2026Article
148 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
19 authors.
Niha BeigFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).ORCID 0000-0002-1150-5886
Mohammadhadi KhorramiFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).ORCID 0000-0002-4141-8548
Mehdi AlilouFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).
Prateek PrasannaFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).
Nathaniel BramanFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).
Mahdi OroojiFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).
Sagar RakshitFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).
Kaustav BeraFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).
Prabhakar RajiahFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).ORCID 0000-0001-7538-385X
Jennifer GinsbergFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).
Christopher DonatelliFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).
Rajat ThawaniFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).
Michael YangFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).
Frank JaconoFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).
Pallavi TiwariFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).
Vamsidhar VelchetiFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).
Robert GilkesonFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).
Philip LindenFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).
Anant MadabhushiFrom the Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Dr, Wickenden 523, Cleveland, OH 44106-7207 (N. Beig, M.K., M.A., P.P., N. Braman, M.O., K.B., P.T., A.M.); Taussig Cancer Institute-Cleveland Clinic, Cleveland, Ohio (S.R.); Division of Thoracic and Esophageal Surgery (J.G., P.L.), Division of Pulmonary Critical Care and Sleep Medicine (C.D., F.J.), Department of Pathology (M.Y.), and Department of Radiology (R.G.), University Hospitals of Cleveland, Cleveland, Ohio; Pulmonary Section, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio (F.J.); Department of Radiology, UT Southwestern Medical Center, Dallas, Tex (P.R.); Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY (R.T.); and Hematology and Oncology, New York University, Perlmutter Cancer Center, New York, NY (V.V.).
Funding
Computerized histologic image predictor of cancer outcomeR01CA202752 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI FELDMAN, MICHAEL D, GANESAN, SHRIDAR · 2016 to 2020
$3.1MQuantitative Histomorphometric Risk Classifier (QuHbIC) in HPV + Oropharyngeal CarcinomaR01CA220581 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI KOYFMAN, SHLOMO, LEWIS, JAMES · 2018 to 2023
$3.1MComputerized Histologic Risk Predictor (CHiRP) for Early Stage Lung CancersR01CA216579 · NCI · EMORY UNIVERSITY · PI FU, PINGFU, LLOYD, MARK · 2018 to 2023
$3.1MMR Fingerprinting and Computerized Decision Support for Prostate CancerR01CA208236 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GULANI, VIKAS, PONSKY, LEE EVAN · 2017 to 2022
$3.0MPathology Image Informatics Platform for visualization, analysis and managementU24CA199374 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI GURCAN, METIN NAFI, MADABHUSHI, ANANT · 2015 to 2019
$2.9MRadiogenomic tools for prediction of breast cancer neo-adjuvant chemotherapy response from pre-treatment MRIF31CA221383 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI BRAMAN, NATHANIEL · 2018 to 2019
$85kBIOMEDICAL ENGINEERING RESEARCH FACILITIESC06RR012463 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI KUTINA, KENNETH L · 1997 to 1997
–BLRD VA I01 BX004121NCI NIH HHS F31 CA221383NCI NIH HHS R01 CA202752NCI NIH HHS R01 CA208236NCI NIH HHS R01 CA216579NCI NIH HHS R01 CA220581NCI NIH HHS U24 CA199374NCRR NIH HHS C06 RR012463
Abstract
Purpose To evaluate ability of radiomic (computer-extracted imaging) features to distinguish non-small cell lung cancer adenocarcinomas from granulomas at noncontrast CT. Materials and Methods For this retrospective study, screening or standard diagnostic noncontrast CT images were collected for 290 patients (mean age, 68 years; range, 18-92 years; 125 men [mean age, 67 years; range, 18-90 years] and 165 women [mean age, 68 years; range, 33-92 years]) from two institutions between 2007 and 2013. Histopathologic analysis was available for one nodule per patient. Corresponding nodule of interest was identified on axial CT images by a radiologist with manual annotation. Nodule shape, wavelet (Gabor), and texture-based (Haralick and Laws energy) features were extracted from intra- and perinodular regions. Features were pruned to train machine learning classifiers with 145 patients. In a test set of 145 patients, classifier results were compared against a convolutional neural network (CNN) and diagnostic readings of two radiologists. Results Support vector machine classifier with intranodular radiomic features achieved an area under the receiver operating characteristic curve (AUC) of 0.75 on the test set. Combining radiomics of intranodular with perinodular regions improved the AUC to 0.80. On the same test set, CNN resulted in an AUC of 0.76. Radiologist readers achieved AUCs of 0.61 and 0.60, respectively. Conclusion Radiomic features from intranodular and perinodular regions of nodules can distinguish non-small cell lung cancer adenocarcinomas from benign granulomas at noncontrast CT. © RSNA, 2018 Online supplemental material is available for this article. See also the editorial by Nishino in this issue.
Indexed as
AdenocarcinomaAdolescentAdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungDiagnosis, DifferentialFemaleGranulomaHumansLung DiseasesLung NeoplasmsMaleMiddle AgedRadiographic Image Interpretation, Computer-AssistedSolitary Pulmonary Nodule
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.