ArticleJournal of the American Heart Association2018
Lung Function in Young Adults and Risk of Cardiovascular Events Over 29 Years: The CARDIA Study.
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Household Air Pollution and Child Lung Function: The Ghana Randomized Air Pollution and Health Study.American journal of respiratory and critical care medicine · 2024Trial
- Prognostic value of long-term trajectory linearity in rapid lung function decline.ERJ open research · 2026Article
- Review
- Cardiovascular and Functional Consequences of Lung Function Impairment in Northern Thai Agricultural Workers.International journal of environmental research and public health · 2025Article
- Associations between cerebral small vessel disease and reduced forced vital capacity and expiratory volume in a general healthy Swedish elder population study-Good Aging in Skåne.Journal of Alzheimer's disease : JAD · 2025Article
- Article
- Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study.BMJ open respiratory research · 2025Article
- Exploring the Impact of Inhaled Corticosteroids on Endothelial Function in Chronic Obstructive Pulmonary Disease Patients Undergoing Pulmonary Rehabilitation.Journal of clinical medicine · 2024Article
- Article
- Determinants of lung function development from birth to age 5 years: an interrupted time series analysis of a South African birth cohort.The Lancet. Child & adolescent health · 2024Article
- Gender Difference in the Relationship between Extrapulmonary Factors and Reduced Lung Function in Early Adulthood.Journal of clinical medicine · 2024Article
- Exploring the association between asthma and chronic comorbidities: impact on clinical outcomes.Frontiers in medicine · 2024Review
- Obstructive and restrictive spirometry from school age to adulthood: three birth cohort studies.EClinicalMedicine · 2024Article
- Low lung function in Bipolar Disorder and Schizophrenia: a hidden risk.Frontiers in physiology · 2024Article
- Association Between End-Stage Liver Disease and Incident Heart Failure in an Integrated Health System.Journal of general internal medicine · 2023Article
- The relationship between preserved ratio impaired spirometry and mortality in the myocardial infarction survivors: a population-based cohort study.BMC cardiovascular disorders · 2023Article
- Evolution of Lung Function within Individuals: Clinical Insights and Data-driven Methods.American journal of respiratory and critical care medicine · 2023Article
- Pulmonary Function in Midlife as a Predictor of Later-Life Cognition: The Coronary Artery Risk Development in Adults (CARDIA) Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- The interaction effect of grip strength and lung function (especially FVC) on cardiovascular diseases: a prospective cohort study in Jiangsu Province, China.Journal of geriatric cardiology : JGC · 2022Article
- Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission.Lancet (London, England) · 2022Review
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Authors and funding
13 authors.
Funding
Abstract
Background Diminished peak lung function in young adulthood is a risk factor for future chronic obstructive pulmonary disease. The association between lung disease and cardiovascular disease later in life is well documented. Whether peak lung function measured in young adulthood is associated with risk of future cardiovascular events is unknown. Methods and Results CARDIA (The Coronary Artery Risk Development in Young Adults) study is a prospective, multicenter, community-based, longitudinal cohort study including 4761 participants aged 18 to 30 years with lung function testing we investigated the association between lung health in young adulthood and risk of subsequent cardiovascular events. We performed Cox proportional hazards regression to test the association between baseline and years 10 and 20 pulmonary function with incident cardiovascular events. Linear and logistic regression was performed to explore the associations of lung function with development of risk factors for cardiovascular disease as well as carotid intima-media thickness and coronary artery calcified plaque. At baseline, mean age (± SD ) was 24.9±3.6 years. Baseline forced expiratory volume in 1 second (hazard ratio) per -10-unit decrement in percent predicted forced expiratory volume in 1 second (hazard ratio, 1.18; 95% CI, 1.06-1.31 [ P=0.002]) and FVC per -10-unit decrement in percent predicted FVC (hazard ratio, 1.19; 95% CI, 1.06-1.33 [ P=0.003]) were associated with future cardiovascular events independent of traditional cardiovascular risk factors. Baseline lung function was associated with heart failure and cerebrovascular events but not coronary artery disease events. Conclusions Lung function in young adulthood is independently associated with cardiovascular events into middle age. This association appears to be driven by heart failure and cerebrovascular events rather than coronary heart disease. Clinical Trial Registration URL : https://www.clinicaltrials.gov . Unique identifier: NCT 00005130.
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