ArticleJournal of veterinary internal medicine2019
Hepatic copper accumulation in a young cat with familial variations in the ATP7B gene.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Copper analysis of laparoscopic liver biopsy tissue samples from cats.The Journal of veterinary medical science · 2026Article
- Quantitative bioimaging of copper in frozen liver specimens from cats using laser ablation-inductively coupled plasma-mass spectrometry.Journal of feline medicine and surgery · 2023Article
- Evaluation of iron, copper and zinc concentrations in commercial foods formulated for healthy cats.Journal of feline medicine and surgery · 2022Article
- A domestic cat whole exome sequencing resource for trait discovery.Scientific reports · 2021Article
- COMMD1 Exemplifies the Power of Inbred Dogs to Dissect Genetic Causes of Rare Copper-Related Disorders.Animals : an open access journal from MDPI · 2021Review
- Variations inJournal of feline medicine and surgery · 2020Article
- Hepatic copper accumulation in a young cat with familial variations in the ATP7B gene.Journal of veterinary internal medicine · 2019Article
- Diagnosis, management and genetic analysis of a cat with primary copper hepatopathy.JFMS open reportsArticle
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 9-month-old intact crossbred female cat was presented with jaundice, intermittent anorexia and lethargy, increased hepatic enzyme activities, and hyperammonemia. Abdominal ultrasound and computed tomographic examinations determined that the liver had a rounded and irregular margin, and histopathological examination identified excessive accumulation of copper hepatocytes in the liver. Concentrations of both blood and urine copper were higher than in healthy cats. The patient responded well to treatment with penicillamine. Clinicopathological abnormalities and clinical signs improved within 2 months, and the patient was alive for >9 months after starting treatment. Genetic examination determined that the patient and its littermate had a single-nucleotide variation (SNV, p. T1297R) that impaired the function of the ATP7B gene product; the gene that is mutated in patients with Wilson's disease (WD). Hepatic copper accumulation was believed to be associated with the SNV of the ATP7B gene, and the patient had a genetic disorder of copper metabolism equivalent to WD in humans.
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