Evidence map›Paper›PMID 30560905›Full record

ArticleScientific reports2018

Comparison of diffusion-weighted MRI and anti-Stokes Raman scattering (CARS) measurements of the inter-compartmental exchange-time of water in expression-controlled aquaporin-4 cells.

Takayuki Obata, Jeff Kershaw, Yasuhiko Tachibana, Takayuki Miyauchi, Yoichiro Abe, Sayaka Shibata, Hiroshi Kawaguchi, Yoko Ikoma, Hiroyuki Takuwa, Ichio Aoki and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. The Glymphatic System: A Review of the Challenges in Visualizing its Structure and Function with MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Monte Carlo Simulator for Diffusion-weighted Imaging Sequences.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2021
    Article
  11. Article
  12. Imaging of Hypoxic Tumor: Correlation between Diffusion-weighted MR Imaging andMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2020
    Article
  13. Based on Histogram Analysis: ADCScientific reports · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Takayuki ObataApplied MRI Research, National Institute of Radiological Sciences, QST, Chiba, 263-8555, Japan. obata.takayuki@qst.go.jp.ORCID http://orcid.org/0000-0001-7678-5033
Jeff KershawApplied MRI Research, National Institute of Radiological Sciences, QST, Chiba, 263-8555, Japan.
Yasuhiko TachibanaApplied MRI Research, National Institute of Radiological Sciences, QST, Chiba, 263-8555, Japan.
Takayuki MiyauchiDepartment of Pharmacology, Keio University School of medicine, Tokyo, 160-0016, Japan.
Yoichiro AbeDepartment of Pharmacology, Keio University School of medicine, Tokyo, 160-0016, Japan.ORCID http://orcid.org/0000-0001-6163-8794
Sayaka ShibataDepartment of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, QST, Chiba, 263-8555, Japan.
Hiroshi KawaguchiHuman Informatics Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, 305-8566, Japan.
Yoko IkomaApplied MRI Research, National Institute of Radiological Sciences, QST, Chiba, 263-8555, Japan.
Hiroyuki TakuwaDepartment of Functional Brain Imaging Research, National Institute of Radiological Sciences, QST, Chiba, 263-8555, Japan.
Ichio AokiDepartment of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, QST, Chiba, 263-8555, Japan.ORCID http://orcid.org/0000-0002-4429-5053
Masato YasuiDepartment of Pharmacology, Keio University School of medicine, Tokyo, 160-0016, Japan.
Keio University · JPNational Institutes for Quantum Science and Technology · JPNational Institute of Advanced Industrial Science and Technology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We performed multi-b and multi-diffusion-time diffusion-weighted magnetic resonance imaging on aquaporin-4-expressing (AQ) and -non-expressing (noAQ) cells, and demonstrated a clear difference between the signals from the two cell types. The data were interpreted using a two-compartment (intra and extracellular spaces) model including inter-compartmental exchange. It was also assumed that restricted diffusion of water molecules inside the cells leads to the intracellular diffusion coefficient being inversely proportional to the diffusion-time. Estimates of the water-exchange-times obtained with this model are compared to those measured using an independent optical imaging technique (coherent anti-Stokes Raman scattering imaging, CARS). For both techniques it was found that the exchange-time estimated for the noAQ cells was significantly longer than that for the AQ cells.

Indexed as

Diffusion Magnetic Resonance ImagingMolecular ImagingSpectrum Analysis, RamanAquaporin 4Extracellular SpaceIntracellular SpaceModels, TheoreticalWaterAquaporin 4Water

Identifiers

PMID30560905
PMCPMC6298983
OpenAlexW2904898365

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.