ArticleScientific reports2018
The effects of a human food additive, titanium dioxide nanoparticles E171, on Drosophila melanogaster - a 20 generation dietary exposure experiment.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 55 citations in OpenAlex.
- Methods to Study DNA Damage Using Drosophila melanogaster.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Metabolic effects of dietary exposure to polystyrene microplastic and nanoplastic in fruit flies.The Journal of experimental biology · 2025Article
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- The heart of plastic: utilizing theFrontiers in toxicology · 2024Article
- Metal Oxide Nanoparticles in Food Packaging and Their Influence on Human Health.Foods (Basel, Switzerland) · 2023Review
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- Effects of Particle Size and Surface Charge on Mutagenicity and Chicken Embryonic Toxicity of New Silver Nanoclusters.ACS omega · 2022Article
- Drosophila as a Suitable In Vivo Model in the Safety Assessment of Nanomaterials.Advances in experimental medicine and biology · 2022Article
- Exposure to food additive mixtures in 106,000 French adults from the NutriNet-Santé cohort.Scientific reports · 2021Article
- Identification of the phase composition of solid microparticles in the nasal mucosa of patients with chronic hypertrophic rhinitis using Raman microspectroscopy.Scientific reports · 2021Observational
- Effects of ingested nanocellulose and nanochitosan materials on carbohydrate digestion and absorption in an in vitro small intestinal epithelium model.Environmental science. Nano · 2021Article
- Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System.International journal of molecular sciences · 2020Review
- Toxicity Assessment of SiOMolecules (Basel, Switzerland) · 2020Article
- Effects of ingested nanocellulose on intestinal microbiota and homeostasis in Wistar Han rats.NanoImpact · 2020Article
- Co-exposure to the food additives SiOEnvironmental science. Nano · 2019Article
- Toxicological effects of ingested nanocellulose in in vitro intestinal epithelium and in vivo rat models.Environmental science. Nano · 2019Article
- EFSA statement on the review of the risks related to the exposure to the food additive titanium dioxide (E 171) performed by the French Agency for Food, Environmental and Occupational Health and Safety (ANSES).EFSA journal. European Food Safety Authority · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, fruit flies (Drosophila melanogaster) were exposed to an estimated daily human E171 consumption concentration for 20 generations. Exposure to E171 resulted in: a change in normal developmental and reproductive dynamics, reduced fecundity after repetitive breeding, increased genotoxicity, the appearance of aberrant phenotypes and morphologic changes to the adult fat body. Marks of adaptive evolution and directional selection were also exhibited. The larval stages were at a higher risk of sustaining damage from E171 as they had a slower elimination rate of TiO
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