ArticleAnnals of intensive care2018
ICU survival and need of renal replacement therapy with respect to AKI duration in critically ill patients.
Article in Annals of intensive care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05247502 (Impact of the Characteristics of Acute Renal Failure in Intensive Care on the Long-term Renal Prognosis), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of the Characteristics of Acute Renal Failure in Intensive Care on the Long-term Renal Prognosis: Prospective Multicenter Cohort Study
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biomarkers for assessing acute kidney injury for people who are being considered for admission to critical care: a systematic review and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2022Pooled it
- Development and external validation of a prediction model for major adverse kidney events within 30 days in sepsis associated acute kidney injury: a multi-center retrospective clinical study.BMC medical informatics and decision making · 2026Article
- Model-informed identification of optimised dosing strategies for meropenem in critically ill patients receiving SLEDD: an observational study.Infection · 2025Observational
- The combination of kidney function variables with cell cycle arrest biomarkers identifies distinct subphenotypes of sepsis-associated acute kidney injury: aRenal failure · 2024Article
- Performance of urinary C-C motif chemokine ligand 14 and the renal resistive index in predicting persistent AKI.Renal failure · 2024Observational
- A Mild Increase in Serum Creatinine after Surgery Is Associated with Increased Mortality.Journal of clinical medicine · 2024Article
- Acute Kidney Injury: Advances in Clinical Management.Journal of clinical medicine · 2022Article
- Performance of the renal resistive index and usual clinical indicators in predicting persistent AKI.Renal failure · 2022Article
- Outcomes After Prolonged ICU Stays in Postoperative Cardiac Surgery Patients.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2022Article
- Recovery of Renal Function in Clinical Patients with Acute Kidney Injury: Impact on Mortality.Life (Basel, Switzerland) · 2022Article
- Early recovery status and outcomes after sepsis-associated acute kidney injury in critically ill patients.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Overview of Renal Replacement Therapy Use in a General Intensive Care Unit.International journal of environmental research and public health · 2022Observational
- Machine learning for early discrimination between transient and persistent acute kidney injury in critically ill patients with sepsis.Scientific reports · 2021Article
- Community prescribing of potentially nephrotoxic drugs and risk of acute kidney injury requiring renal replacement therapy in critically ill adults: A national cohort study.Journal of the Intensive Care Society · 2021Article
- Development and External Verification of a Nomogram for Patients with Persistent Acute Kidney Injury in the Intensive Care Unit.International journal of general medicine · 2021Article
- Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury.Molecules (Basel, Switzerland) · 2020Review
- Comparing outcomes of hospitalized patients with moderate and severe COVID-19 following treatment with hydroxychloroquine plus atazanavir/ritonavir.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2020Article
- Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis: a prospective cohort study.Intensive care medicine · 2020Article
- Urine cell cycle arrest biomarkers distinguish poorly between transient and persistent AKI in early septic shock: a prospective, multicenter study.Critical care (London, England) · 2020Article
- Incidence, Risk Factors, and Outcome of Acute Kidney Injury in the Intensive Care Unit: A Single-Center Study from Jordan.Critical care research and practice · 2020Article
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20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransient and persistent acute kidney injury (AKI) could share similar physiopathological mechanisms. The objective of our study was to assess prognostic impact of AKI duration on ICU mortality.
designRetrospective analysis of a prospective database via cause-specific model, with 28-day ICU mortality as primary end point, considering discharge alive as a competing event and taking into account time-dependent nature of renal recovery. Renal recovery was defined as a decrease of at least one KDIGO class compared to the previous day.
setting23 French ICUs. PATIENTS: Patients of a French multicentric observational cohort were included if they suffered from AKI at ICU admission between 1996 and 2015.
interventionNone.
resultsA total of 5242 patients were included. Initial severity according to KDIGO creatinine definition was AKI stage 1 for 2458 patients (46.89%), AKI stage 2 for 1181 (22.53%) and AKI stage 3 for 1603 (30.58%). Crude 28-day ICU mortality according to AKI severity was 22.74% (n = 559), 27.69% (n = 327) and 26.26% (n = 421), respectively. Renal recovery was experienced by 3085 patients (58.85%), and its rate was significantly different between AKI severity stages (P < 0.01). Twenty-eight-day ICU mortality was independently lower in patients experiencing renal recovery [CSHR 0.54 (95% CI 0.46-0.63), P < 0.01]. Lastly, RRT requirement was strongly associated with persistent AKI whichever threshold was chosen between day 2 and 7 to delineate transient from persistent AKI.
conclusionsShort-term renal recovery, according to several definitions, was independently associated with higher mortality and RRT requirement. Moreover, distinction between transient and persistent AKI is consequently a clinically relevant surrogate outcome variable for diagnostic testing in critically ill patients.
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