Evidence map›Paper›PMID 30560438›Full record

ReviewNeuroscience bulletin2019

Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury.

Qian Huang, Wanru Duan, Eellan Sivanesan, Shuguang Liu, Fei Yang, Zhiyong Chen, Neil C Ford, Xueming Chen, Yun Guan

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Qian HuangDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
Wanru DuanDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
Eellan SivanesanDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
Shuguang LiuDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
Fei YangDepartment of Neurobiology, Capital Medical University, Beijing, 100069, China.
Zhiyong ChenDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
Neil C FordDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
Xueming ChenDepartment of Orthopedics, Luhe Hospital, Capital Medical University, Beijing, 100020, China.
Yun GuanDepartment of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA. yguan1@jhmi.edu.
Johns Hopkins Medicine · USJohns Hopkins University · USBeijing Luhe Hospital Affiliated to Capital Medical University · CNCapital Medical University · CN

Funding

Program in Postdoctoral Research Training in AnesthesiologyT32GM075774 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI SAPNA R KUDCHADKAR, Emmett E Whitaker · 2006 to 2026
$8.1M
Mrgs as New Target for the Treatment of Neuropathic PainR01NS070814 · NINDS · JOHNS HOPKINS UNIVERSITY · PI GUAN, YUN · 2011 to 2020
$3.2M
CRCNS: Towards Pain Control: Synergizing Computational and Biological ApproachesR01AT009401 · NCCIH · JOHNS HOPKINS UNIVERSITY · PI SARMA, SRIDEVI V. · 2016 to 2019
$1.6M
Developing Novel Direct Current Stimulation Technology for Safe Precision Pain TreatmentR21NS099879 · NINDS · JOHNS HOPKINS UNIVERSITY · PI GUAN, YUN · 2016 to 2017
$449k
NCCIH NIH HHS R01 AT009401NIGMS NIH HHS T32 GM075774NINDS NIH HHS R01 NS070814NINDS NIH HHS R21 NS099879
6 · The paper itself

Abstract

In addition to restoration of bladder, bowel, and motor functions, alleviating the accompanying debilitating pain is equally important for improving the quality of life of patients with spinal cord injury (SCI). Currently, however, the treatment of chronic pain after SCI remains a largely unmet need. Electrical spinal cord stimulation (SCS) has been used to manage a variety of chronic pain conditions that are refractory to pharmacotherapy. Yet, its efficacy, benefit profiles, and mechanisms of action in SCI pain remain elusive, due to limited research, methodological weaknesses in previous clinical studies, and a lack of mechanistic exploration of SCS for SCI pain control. We aim to review recent studies and outline the therapeutic potential of different SCS paradigms for traumatic SCI pain. We begin with an overview of its manifestations, classification, potential underlying etiology, and current challenges for its treatment. The clinical evidence for using SCS in SCI pain is then reviewed. Finally, future perspectives of pre-clinical research and clinical study of SCS for SCI pain treatment are discussed.

Indexed as

Spinal Cord StimulationAnimalsChronic PainHumansPainPain ManagementQuality of LifeSpinal Cord InjuriesTreatment OutcomeAnalgesiaNeuromodulationPainSpinal cord injurySpinal cord stimulationTrauma

Identifiers

PMID30560438
PMCPMC6527651
OpenAlexW2904218816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.