Evidence map›Paper›PMID 30560355›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2019

Salvianolic acid A inhibits tumor-associated angiogenesis by blocking GRP78 secretion.

Yufei Yang, Lichao Zhang, Xiaoqin La, Zhuoyu Li, Hanqing Li, Songjia Guo

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  9. Linking Variability in Phytochemical Composition with Safety Profile ofInternational journal of molecular sciences · 2024
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  13. Underlying mechanisms and drug intervention strategies for the tumour microenvironment.Journal of experimental & clinical cancer research : CR · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yufei YangInstitute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan, 030006, China.
Lichao ZhangInstitutes of Biomedical Sciences, Shanxi University, Taiyuan, 030006, China.
Xiaoqin LaInstitute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan, 030006, China.
Zhuoyu LiInstitute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan, 030006, China. lzy@sxu.edu.cn.
Hanqing LiSchool of Life Science, Shanxi University, Taiyuan, 030006, China.
Songjia GuoPrecision medical center, Shanxi Province People's Hospital, Taiyuan, China.
Shanxi University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucose-regulated protein 78 (GRP78) often highly expresses in a wide range of tumors, which plays promotive functions due to its diversity of location in the development of tumor. Particularly, GRP78 can be secreted into microenvironment by tumor cells through the pathway of exosome, which promotes proliferation, angiogenesis, and drug resistance in cancer cells. Hence, we discovered a potential inhibitor to block GRP78 secretion. We screened five small molecules that may interact with the GRP78 from 51 traditional Chinese medicine molecules by molecular docking. By using western blot, we found that one of the molecules can inhibit the secretion of GRP78, which is salvianolic acid A (SAA). Further, SAA could interact with the lysine residue 633 (K633) of GRP78, which inhibited GRP78 secretion. Moreover, SAA-GRP78 interaction can facilitate GRP78 of cytosol sorted into lysosome for degradation rather than exosome. In conclusion, our research revealed that SAA has the novel function of anti-angiogenesis via the tumor environment.

Indexed as

Angiogenesis InhibitorsAnimalsCaffeic AcidsCell LineColonColonic NeoplasmsEndoplasmic Reticulum Chaperone BiPFemaleHeat-Shock ProteinsHumansLactatesMice, NudeMolecular Docking SimulationAngiogenesis InhibitorsCaffeic AcidsEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsHSPA5 protein, humanHspa5 protein, mouseLactatessalvianolic acid AAngiogenesisExosomeInteractionSalvianolic acid ATumor-secreted GRP78

Identifiers

PMID30560355
OpenAlexW2905280797

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.