ReviewTherapeutic advances in ophthalmology
Corneal endothelial cell dysfunction: etiologies and management.
Review in Therapeutic advances in ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
102 citing papers in PubMed, 1 synthesis or guideline pooled it, 173 citations in OpenAlex.
- Emerging treatments for corneal endothelium decompensation - a systematic review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Pooled it
- Comparison of corneal endothelial cell loss during manual small-incision cataract surgery using viscoelastic-assisted nucleus removal versus continuous balanced salt solution plus technique - Randomized controlled trial.Indian journal of ophthalmology · 2022Trial
- Identification of a translatable rabbit model for corneal endothelial dysfunction.Eye (London, England) · 2026Article
- Central corneal endothelial morphometry in emmetropic adults aged 20-40 years examined in Valencia, Spain: a retrospective cross-sectional analysis.Surgical and radiologic anatomy : SRA · 2026Article
- Scanning electron microscopy of artificial corneal endothelial keratoplasty implant.Journal of cataract and refractive surgery · 2026Article
- An Optimized Mechanical Peeling Protocol for Mouse Corneal Endothelium.Bioengineering (Basel, Switzerland) · 2026Article
- Acute Bilateral Corneal Oedema Following Suspected Toxic Endothelial Insult: An Intriguing Case Report.Cureus · 2026Article
- A Viscous DES-AAV-Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria-ER Contacts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Therapeutic Potential of miR-196a in Protecting Corneal Endothelial Cells From Senescence Through Mitochondrial and TGF-β Signaling Modulation.Translational vision science & technology · 2026Article
- Identification of potential therapeutic targetiScience · 2026Article
- Article
- Study of microstructural changes in cornea under different stresses using a custom-made 100 kHz swept-source optical coherence tomography imaging system.International journal of legal medicine · 2026Article
- Corneal edema: an underrecognized safety risk of amantadine.Journal of neurology · 2026Article
- Beyond the Cornea: Systemic Diseases and Their Impact on Endothelial Health-A Narrative Review.Journal of clinical medicine · 2026Review
- Generation of a Novel Col8a2Genesis (New York, N.Y. : 2000) · 2026Article
- [Multilevel revision after complicated cataract surgery. Video article].Die Ophthalmologie · 2026Review
- Neutrophil-to-Lymphocyte Ratio Is Associated with the Stability of Human Corneal Endothelial Cells.Journal of clinical medicine · 2026Article
- Recent advances in corneal specular microscopy image analysis through artificial intelligence.PLOS digital health · 2026Review
- A Hospital-Based Cross-Sectional Study on the Suboptimal Use of Eye Protective Devices (EPDs) Among Blue-Collar Professionals in India.Journal of pharmacy & bioallied sciences · 2026Article
- Review
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A transparent cornea is essential for the formation of a clear image on the retina. The human cornea is arranged into well-organized layers, and each layer plays a significant role in maintaining the transparency and viability of the tissue. The endothelium has both barrier and pump functions, which are important for the maintenance of corneal clarity. Many etiologies, including Fuchs' endothelial corneal dystrophy, surgical trauma, and congenital hereditary endothelial dystrophy, lead to endothelial cell dysfunction. The main treatment for corneal decompensation is replacement of the abnormal corneal layers with normal donor tissue. Nowadays, the trend is to perform selective endothelial keratoplasty, including Descemet stripping automated endothelial keratoplasty and Descemet's membrane endothelial keratoplasty, to manage corneal endothelial dysfunction. This selective approach has several advantages over penetrating keratoplasty, including rapid recovery of visual acuity, less likelihood of graft rejection, and better patient satisfaction. However, the global limitation in the supply of donor corneas is becoming an increasing challenge, necessitating alternatives to reduce this demand. Consequently,
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.