ArticleArthroplasty today2018
Intrawound vancomycin in primary hip and knee arthroplasty: a safe and cost-effective means to decrease early periprosthetic joint infection.
Article in Arthroplasty today, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Intrawound vancomycin powder for prevention of surgical site infections in primary joint arthroplasty: an umbrella review of systematic reviews and meta-analyses.International journal of surgery (London, England) · 2025Pooled it
- Prophylactic use of vancomycin powder on postoperative infection after total joint arthroplasty.BMC musculoskeletal disorders · 2024Pooled it
- Effects of different doses of vancomycin powder in total knee and hip arthroplasty on the periprosthetic joint infection rate: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2022Pooled it
- Effectiveness of diluted povidone-iodine lavage for preventing periprosthetic joint infection: an updated systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2021Pooled it
- Local antibiotics in primary hip and knee arthroplasty: a systematic review and meta-analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2021Pooled it
- Intrawound Vancomycin and Povidone-Iodine Treatment to Reduce Infection Rates in Arthroplasty.Journal of orthopaedic case reports · 2026Article
- Propellant-free intrawound antibiotic foam for intraoperative antimicrobial prophylaxis.Drug delivery and translational research · 2026Article
- Only a partial shield: local vancomycin postpones but does not prevent hip and knee prosthetic infections.Archives of orthopaedic and trauma surgery · 2026Article
- Use of intraoperative vancomycin powder and its effects on the incidence of surgical site infection in orthopaedic trauma: a systematic review with meta-analysis.OTA international : the open access journal of orthopaedic trauma · 2026Article
- Cemented implantation of a dual mobility cup in an existing acetabular cup to prevent recurrent dislocation after total hip replacement.Orthopadie (Heidelberg, Germany) · 2026Article
- Infected total knee arthroplasty: could cotrimoxazole be the answer?European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- The use of vancomycin powder in total elbow arthroplasty; can we decrease infection risk?JSES reviews, reports, and techniques · 2025Article
- The Role of Intrawound Vancomycin Powder in Reducing Surgical Site Infections in Orthopedic Surgery: A Comprehensive Narrative Review of Its Efficacy, Safety, and Applications.Indian journal of orthopaedics · 2025Review
- Use of vancomycin powder under polyethylene in total knee arthroplasty: a technical note.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- Effectiveness of Local Antibiotics for Infection Prevention in Primary Joint Arthroplasty: A Systematic Review and Meta-Analysis.Antibiotics (Basel, Switzerland) · 2025Review
- Analysis of systemic serum vancomycin levels following intraarticular application in primary total joint arthroplasty.Archives of orthopaedic and trauma surgery · 2024Article
- Efficacy and safety of vancomycin for local application in the prevention of surgical site infection after joint arthroplasty: a systematic review and meta-analysis.EFORT open reviews · 2024Article
- The effect of different preventive strategies during total joint arthroplasty on periprosthetic joint infection: a network meta-analysis.Journal of orthopaedic surgery and research · 2024Article
- Intra-articular Vancomycin Reduces Prosthetic Infection in Primary Hip and Knee Arthroplasty.Arthroplasty today · 2024Article
- Topical Application of Vancomycin Powder to Prevent Infections after Massive Bone Resection and the implantation of Megaprostheses in Orthopaedic Oncology Surgery.Malaysian orthopaedic journal · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriprosthetic joint infection (PJI) is a devastating complication after hip and knee arthroplasty. Intrawound vancomycin has been described extensively in the spine literature; however, information regarding use in arthroplasty is limited. We investigate the efficacy and safety of intrawound vancomycin in arthroplasty surgery.
methodsAll primary total hip and knee arthroplasty cases (n = 460) performed by a single surgeon from April 2016 to October 2017 were reviewed. Starting in October 2016, intrawound vancomycin was used in all total joints. Baseline characteristics, infection rates, 90-day readmission, and other complications were compared between untreated subjects and those who received intrawound vancomycin. In addition, cost data were considered. Mean follow-up durations for the control and vancomycin groups were 11.3 and 7.7 months, respectively.
resultsBaseline characteristics and comorbidities were similar for the control (n = 112) and vancomycin groups (n = 348). The vancomycin cohort demonstrated decreased both overall infection rate (0.57% vs 2.7%;
conclusionsThese findings suggest that intrawound vancomycin may be a safe, cost-effective means that shows promise in reducing PJI in early follow-up. Future prospective studies are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.