ArticleMultiple sclerosis journal - experimental, translational and clinical
Factors associated with time from first-symptoms to diagnosis and treatment initiation of Multiple Sclerosis in Switzerland.
Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05438693 (Factors Affecting Time Elapsed From First Symptom Till Complete Diagnosis of Multiple Sclerosis, Initiation of Disease Modifying Treatment and Drug Adherence in Upper Egypt), which is not on this map. Cited by 19 papers.
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Factors Affecting Time Elapsed From First Symptom Till Complete Diagnosis of Multiple Sclerosis, Initiation of Disease Modifying Treatment and Drug Adherence in Upper Egypt
Who cites it
19 citing papers in PubMed.
- Factors influencing patient satisfaction with the first diagnostic consultation in multiple sclerosis: a Swiss Multiple Sclerosis Registry (SMSR) study.Journal of neurology · 2020Trial
- Article
- Diagnostic Delay in Multiple Sclerosis in China: A Nationwide Cross-Sectional Study.Advances in therapy · 2026Article
- Methods of estimating prevalence of multiple sclerosis in six European healthcare data sources: a contribution from the ConcePTION project.European journal of epidemiology · 2026Article
- Bladder, bowel, and sexual dysfunction are overlooked in the management of neurological conditions: a qualitative interview study.BMC neurology · 2026Article
- Atypical Presentations at Risk for Diagnostic Errors in Internal Medicine: A Scoping Review.Journal of general internal medicine · 2026Article
- Multiple sclerosis patients' journey delay in diagnosis and treatment: a multicenter study.BMC neurology · 2025Observational
- Consensus-Based Guidelines for Communicating a Misdiagnosis of Multiple Sclerosis to Reduce Psychological Distress.Brain and behavior · 2024Article
- Quantitative TEuropean radiology · 2024Article
- Building digital patient pathways for the management and treatment of multiple sclerosis.Frontiers in immunology · 2024Review
- Diagnostic delay of multiple sclerosis: prevalence, determinants and consequences.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Multiple sclerosis diagnostic delay and its associated factors in Upper Egyptian patients.Scientific reports · 2023Article
- Prior optic neuritis detection on peripapillary ring scans using deep learning.Annals of clinical and translational neurology · 2022Article
- Familial co-aggregation of attention-deficit/hyperactivity disorder and autoimmune diseases: a cohort study based on Swedish population-wide registers.International journal of epidemiology · 2022Article
- Onset Symptom Clusters in Multiple Sclerosis: Characteristics, Comorbidities, and Risk Factors.Frontiers in neurology · 2021Article
- How do patients enter the healthcare system after the first onset of multiple sclerosis symptoms? The influence of setting and physician specialty on speed of diagnosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020Observational
- Delays in treatment initiation for patients with relapsing-remitting multiple sclerosis-A nationwide population-based study.Multiple sclerosis journal - experimental, translational and clinicalArticle
- Diagnostic delay and misdiagnosis of symptoms reported by patients with multiple sclerosis participating in a research registry.Multiple sclerosis journal - experimental, translational and clinicalArticle
- Driving time-based identification of gaps in specialised care coverage: An example of neuroinflammatory diseases in Germany.Digital healthArticle
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies emphasise the importance of timely diagnosis and early initiation of disease-modifying treatment in the long-term prognosis of multiple sclerosis.
objectivesThe objective of this study was to investigate factors associated with extended time to diagnosis and time to disease-modifying treatment initiation in the Swiss Multiple Sclerosis Registry.
methodsWe used retrospective data (diagnoses 1996-2017) of the survey-based Swiss Multiple Sclerosis Registry and fitted logistic regression models (extended time to diagnosis ≥2 years from first symptoms, extended time to disease-modifying treatment initiation ≥1 year from diagnosis) with demographic and a priori defined variables.
resultsOur study, based on 996 persons with multiple sclerosis, suggests that 40% had an extended time to diagnosis, and extended time to disease-modifying treatment initiation was seen in 23%. Factors associated with extended time to diagnosis were primary progressive multiple sclerosis (odds ratio (OR) 5.09 (3.12-8.49)), diagnosis setting outside of hospital (neurologist (private practice) OR 1.54 (1.16-2.05)) and more uncommon first symptoms (per additional symptom OR 1.17 (1.06-1.30)). Older age at onset (per additional 5 years OR 0.84 (0.78-0.90)) and gait problems (OR 0.65 (0.47-0.89)) or paresthesia (OR 0.72 (0.54-0.95)) as first symptoms were associated with shorter time to diagnosis. Extended time to disease-modifying treatment initiation was associated with older age at diagnosis (per additional 5 years OR 1.18 (1.09-1.29)). In more recent years, time to diagnosis and time to disease-modifying treatment initiation tended to be shorter.
conclusionsEven in recent periods, substantial and partially systematic variation regarding time to diagnosis and time to disease-modifying treatment initiation remains. With the emerging paradigm of early treatment, the residual variation should be monitored carefully.
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