Evidence map›Paper›PMID 30559954›Full record

ArticleMolecular autism2018

Diffusional kurtosis imaging of the corpus callosum in autism.

Yu Veronica Sui, Jeffrey Donaldson, Laura Miles, James S Babb, Francisco Xavier Castellanos, Mariana Lazar

Open access · goldAbstract read
In one paragraph

Article in Molecular autism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
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  4. In vivo translocator protein in females with autism spectrum disorder: a pilot study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yu Veronica Sui1Department of Radiology, New York University School of Medicine, New York, NY USA.ORCID 0000-0003-3910-984X
Jeffrey Donaldson1Department of Radiology, New York University School of Medicine, New York, NY USA.
Laura Miles1Department of Radiology, New York University School of Medicine, New York, NY USA.
James S Babb1Department of Radiology, New York University School of Medicine, New York, NY USA.
Francisco Xavier Castellanos2Department of Child and Adolescent Psychiatry, Hassenfeld Children's Hospital at NYU Langone, New York, NY USA.
Mariana Lazar1Department of Radiology, New York University School of Medicine, New York, NY USA.
New York University · USNYU Langone Health · USNathan Kline Institute for Psychiatric Research · US

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Hersh Chandarana · 2014 to 2026
$19.3M
Anatomical Connectivity in the Autistic BrainR03MH076180 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LAZAR, MARIANA · 2007 to 2008
$169k
NIBIB NIH HHS P41 EB017183NIMH NIH HHS R03 MH076180
6 · The paper itself

Abstract

Background: The corpus callosum is implicated in the pathophysiology of autism spectrum disorder (ASD). However, specific structural deficits and underlying mechanisms are yet to be well defined. Methods: We employed diffusional kurtosis imaging (DKI) metrics to characterize white matter properties within five discrete segments of the corpus callosum in 17 typically developing (TD) adults and 16 age-matched participants with ASD without co-occurring intellectual disability (ID). The DKI metrics included axonal water fraction ( Results: ASD group had significantly decreased callosal Conclusion: Decreased DKI metrics suggested that ASD may be associated with axonal deficits such as reduced axonal caliber and density in the corpus callosum, especially in the mid and posterior callosal areas. These data suggest that impaired interhemispheric connectivity may contribute to decreased processing speed in ASD participants.

Indexed as

AdolescentAdultAutistic DisorderCase-Control StudiesCorpus CallosumHumansMagnetic Resonance ImagingWechsler ScalesWhite MatterAutismCorpus callosumDiffusional kurtosis imagingInterhemispheric connectivityProcessing speed

Identifiers

PMID30559954
PMCPMC6293510
OpenAlexW2904180476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.