Evidence map›Paper›PMID 30559850›Full record

ArticleOpen access Macedonian journal of medical sciences2018

Cyclooxygenase-2 Expression and Its Correlation with Primary Tumor Size and Lymph Node Involvement in Nasopharyngeal Carcinoma.

Jessy Chrestella, Farhat Farhat, Elvita Rahmi Daulay, Rizalina Arwinati Asnir, Ashri Yudhistira, Indah Afriani Nasution

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
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Article in Open access Macedonian journal of medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jessy ChrestellaUniversitas Sumatera Utara, Fakultas Kedokteran, Pathology, Sumatera Utara, Indonesia.
Farhat FarhatUniversitas Sumatera Utara Fakultas Kedokteran, Otorhinolaryngology Head and Neck Surgery Jl. Dr T. Mansyur No. 9, Medan, North Sumatera 20155, Indonesia.
Elvita Rahmi DaulayUniversitas Sumatera Utara Fakultas Kedokteran, Radiology, Medan, Sumatera Utara, Indonesia.
Rizalina Arwinati AsnirUniversitas Sumatera Utara Fakultas Kedokteran, Otorhinolaryngology Head and Neck Surgery Jl. Dr T. Mansyur No. 9, Medan, North Sumatera 20155, Indonesia.
Ashri YudhistiraUniversitas Sumatera Utara Fakultas Kedokteran, Otorhinolaryngology Head and Neck Surgery Jl. Dr T. Mansyur No. 9, Medan, North Sumatera 20155, Indonesia.
Indah Afriani NasutionUniversitas Sumatera Utara Fakultas Kedokteran, Otorhinolaryngology Head and Neck Surgery Jl. Dr T. Mansyur No. 9, Medan, North Sumatera 20155, Indonesia.
Universitas Sumatera Utara · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study aimed to observe the cyclooxygenase-2 expression and its correlation with tumour size and lymph node involvement in nasopharyngeal carcinoma.

methodsThis study was cross-sectional, that enrolled 126 samples diagnosed with nasopharyngeal carcinoma in Haji Adam Malik General Hospital, Medan, Indonesia which fulfilled the inclusion criteria.

resultsBased on this study, we found that the age peak incidence of nasopharyngeal carcinoma patients about a 41-60-year-old group (57.1%), dominated by men (71.4%). Through histopathological examination, non-keratinizing squamous cell carcinoma is the most predominant type (79.4%). We also found T3 is the most prevalent primary tumour size (32.5%) with prominent lymph node involvement N3 (45.2%), and stage IV (54.8%). Cyclooxygenase-2 overexpression is prevalent among nonkeratinizing squamous cell carcinoma (81.1%), T3 primary tumour size (41.1%), N3 node involvement (60.0%), and IV clinical stage (71.6%). In addition, we found a significant relationship between cyclooxygenase-2 expressions towards tumor size (p < 0.001) and lymph node involvement (p < 0.001) in nasopharyngeal carcinoma.

conclusionIt is proved that the overexpression of cyclooxygenase-2 will increase the susceptibility of nasopharyngeal carcinoma patients having advanced primary tumour size and lymph node involvement.

Indexed as

Cyclooxygenase (COX)-2Lymph node involvementNasopharyngeal carcinomaOverexpressionTumor Size

Identifiers

PMID30559850
PMCPMC6290448
OpenAlexW2901331477

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.