ArticleBiotechnology for biofuels2018
Mechanism and enhancement of lipid accumulation in filamentous oleaginous microalgae
Article in Biotechnology for biofuels, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 58 citations in OpenAlex.
- Combined transcriptomic and proteomic analysis reveals the influence of sulfur availability on nitrogen and carbon metabolism and lipid accumulation in Tribonema minus (Xanthophyceae).Biotechnology for biofuels and bioproducts · 2026Article
- Towards maximizing biomass and lipid productivity: high-throughput screening assay for prospecting heterotrophic growth for new microalgal isolates.Microbial cell factories · 2024Article
- Variability in Macro- and Micronutrients of 15 Rarely Researched Microalgae.Marine drugs · 2023Article
- Alternative microbial-based functional ingredient source for lycopene, beta-carotene, and polyunsaturated fatty acids.Heliyon · 2023Article
- The growth, lipid accumulation and adaptation mechanism in response to variation of temperature and nitrogen supply in psychrotrophic filamentous microalga Xanthonema hormidioides (Xanthophyceae).Biotechnology for biofuels and bioproducts · 2023Article
- Isolation, Characterization and Immunomodulatory Activity Evaluation of Chrysolaminarin from the Filamentous MicroalgaMarine drugs · 2022Article
- Annotated Genome Sequence of the High-Biomass-Producing Yellow-Green Alga Tribonema minus.Microbiology resource announcements · 2021Article
- Cultivation of microalgae on unhydrolysed waste molasses syrup using mass cultivation strategy for improved biodiesel.3 Biotech · 2021Article
- Metabolomic Study of Heterotrophically GrownMolecules (Basel, Switzerland) · 2021Article
- Enhanced Antiobesity Efficacy of Tryptophan Using the Nanoformulation ofMaterials (Basel, Switzerland) · 2021Article
- Molecular Mechanism of Lipid Accumulation and Metabolism of OleaginousInternational journal of molecular sciences · 2021Article
- Biomass, lipid accumulation kinetics, and the transcriptome of heterotrophic oleaginous microalga Tetradesmus bernardii under different carbon and nitrogen sources.Biotechnology for biofuels · 2021Article
- Genetic Transformation ofInternational journal of molecular sciences · 2020Article
- Mucoromycotina Fungi Possess the Ability to Utilize Plant Sucrose as a Carbon Source: Evidence FromFrontiers in microbiology · 2020Article
- Targeted Metabolomic and Biochemical Changes During Nitrogen Stress Mediated Lipid Accumulation inFrontiers in bioengineering and biotechnology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe filamentous microalgae
methodsThe metabolic differences between photoautotrophically and heterotrophically cultivated
resultsCompared to photoautotrophic cultures, heterotrophic cultures exhibited enhanced biomass levels and carbohydrate content, but decreased lipid accumulation. These effects were accompanied by low expression levels of genes involved in glycolysis, de novo fatty acids biosynthesis and lipid biosynthesis, and high levels of genes involved in gluconeogenesis. In addition, the levels of key metabolites involved in glycolysis/gluconeogenesis were elevated in abundance, whereas those of certain fatty acids and citric acid were decreased in heterotrophic cultures. Upon supplementation with exogenous potassium palmitate, the lipid content increased dramatically in heterotrophically cultivated
conclusionAn insufficient supply of carbon precursors caused the low levels of lipid accumulation during heterotrophic cultivation. Appropriate carbon metabolite supplementation based on the metabolomic data was shown to promote lipid accumulation. Moreover, gene regulatory metabolic targets were also identified via omics analysis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.