Evidence map›Paper›PMID 30559764›Full record

ArticleJournal of otology2018

Autonomic responses to blast overpressure can be elicited by exclusively exposing the ear in rats.

David S Sandlin, Yue Yu, Jun Huang, Chunming Zhang, Alberto A Arteaga, John K Lippincott, Erin O H Peeden, Ryan R Guyton, Lan Chen, Laura L S Beneke and 3 more

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of otology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Progression of Vestibular Deficits Following Moderate-Intensity Blast Overpressure in Rats.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

David S SandlinGraduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, USA.
Yue YuDepartment of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, MS, USA.
Jun HuangDepartment of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, MS, USA.
Chunming ZhangDepartment of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, MS, USA.
Alberto A ArteagaDepartment of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, MS, USA.
John K LippincottSchool of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Erin O H PeedenSchool of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Ryan R GuytonGraduate Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, USA.
Lan ChenSummer Undergraduate Research Experience, University of Mississippi Medical Center, Jackson, MS, USA.
Laura L S BenekeSchool of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Jerome C AllisonDepartment of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, MS, USA.
Hong ZhuDepartment of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, MS, USA.
Wu ZhouDepartment of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, MS, USA.
University of Mississippi Medical Center · USJackson Memorial Hospital · USShanxi Medical University · CN

Funding

Neural mechanisms of sound activation of vestibular systemR01DC012060 · NIDCD · UNIVERSITY OF MISSISSIPPI MED CTR · PI ZHU, HONG · 2012 to 2016
$1.9M
NIDCD NIH HHS R01 DC012060
6 · The paper itself

Abstract

Blast overpressure has become an increasing cause of brain injuries in both military and civilian populations. Though blast's direct effects on the cochlea and vestibular organs are active areas of study, little attention has been given to the ear's contribution to the overall spectrum of blast injury. Acute autonomic responses to blast exposure, including bradycardia and hypotension, can cause hypoxia and contribute to blast-induced neurotrauma. Existing literature suggests that these autonomic responses are elicited through blast impacting the thorax and lungs. We hypothesize that the unprotected ear also provides a vulnerable locus for blast to cause autonomic responses. We designed a blast generator that delivers controlled overpressure waves into the ear canal without impacting surrounding tissues in order to study the ear's specific contribution to blast injury. Anesthetized adult rats' left ears were exposed to a single blast wave ranging from 0 to 110 PSI (0-758 kPa). Blast exposed rats exhibited decreased heart rates and blood pressures with increased blast intensity, similar to results gathered using shock tubes and whole-body exposure in the literature. While rats exposed to blasts below 50 PSI (345 kPa) exhibited increased respiratory rate with increased blast intensity, some rats exposed to blasts higher than 50 PSI (345 kPa) stopped breathing immediately and ultimately died. These autonomic responses were significantly reduced in vagally denervated rats, again similar to whole-body exposure literature. These results support the hypothesis that the unprotected ear contributes to the autonomic responses to blast.

Indexed as

Autonomic responsesBlast wavesEarNeurotrauma

Identifiers

PMID30559764
PMCPMC6291641
OpenAlexW2793897493

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.