ArticleFrontiers in behavioral neuroscience2018
A Longer Interstimulus Interval Yields Better Learning in Adults and Young Adolescents.
Article in Frontiers in behavioral neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- C/T Ratios in Human Eyeblink Conditioning Paradigms to Examine Cerebellar Function and ADHD: A Narrative Review.Behavioral sciences (Basel, Switzerland) · 2026Review
- Entirely synthetic memory inception via dual optogenetic activation of sensory and dopaminergic neurons.iScience · 2025Article
- The ability to maintain rhythm is predictive of ADHD diagnosis and profile.BMC psychiatry · 2023Article
- Effects of working memory load and CS-US intervals on delay eyeblink conditioning.NPJ science of learning · 2023Article
- Article
- Weak correlations between cerebellar tests.Scientific reports · 2020Article
- Article
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3 authors.
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Abstract
Eyeblink conditioning is one of the most popular experimental paradigms for studying the neural mechanisms underlying learning and memory. A key parameter in eyeblink conditioning is the interstimulus interval (ISI), the time between the onset of the conditional stimulus (CS) and the onset of the unconditional stimulus (US). Though previous studies have examined how the ISI affects learning there is no clear consensus concerning which ISI is most effective and different researchers use different ISIs. Importantly, the brain undergoes changes throughout life with significant cerebellar growth in adolescents, which could mean that different ISIs might be called for in children, adolescents and adults. Moreover, the fact that animals are often trained with a shorter ISI than humans make direct comparisons problematic. In this study, we compared eyeblink conditioning in young adolescents aged 10-15 and adults using one short ISI (300 ms) and one long ISI (500 ms). The results demonstrate that young adolescents and adults produce a higher percentage of CRs when they are trained with a 500 ms ISI compared to a 300 ms ISI. The results also show that learning is better in the adults, especially for the shorter ISI.
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