ReviewOchsner journal2018
Diagnosis of Tooth Agenesis in Childhood and Risk for Neoplasms in Adulthood.
Review in Ochsner journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Association between tooth agenesis and cancer: a systematic review.Journal of applied oral science : revista FOB · 2021Pooled it
- [Whole genome sequencing and analysis of familial nonsyndromic congenital tooth agenesis].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026Article
- The Role of Genetics in Human Oral Health: A Systematic-Narrative Review.Dentistry journal · 2025Review
- Main genetic entities associated with tooth agenesis.Clinical oral investigations · 2024Review
- A Narrative Review of the Association between Dental Abnormalities and Chemotherapy.Journal of clinical medicine · 2024Review
- Non-syndromic tooth agenesis in Latvian adolescent dental patients: a retrospective study with relevant literature review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Review
- "Examining the link between tooth agenesis and papillary thyroid cancer: is there a risk factor?" Observational study.Progress in orthodontics · 2024Observational
- Oligodontia in the Clinical Spectrum of Syndromes: A Systematic Review.Dentistry journal · 2023Review
- Count Me in, Count Me out: Regulation of the Tooth Number via Three Directional Developmental Patterns.International journal of molecular sciences · 2023Review
- Advances in tooth agenesis and tooth regeneration.Regenerative therapy · 2023Review
- Non-syndromic hypodontia of maxillary lateral incisors and its association with other dental anomalies.Progress in orthodontics · 2022Article
- The Incidence of Dental Caries in Children with Down Syndrome: A Systematic Review and Meta-Analysis.Dentistry journal · 2022Review
- Nonmalignant Features Associated with Inherited Colorectal Cancer Syndromes-Clues for Diagnosis.Cancers · 2022Review
- Three Cases of Bilateral Breast Absence Associated with Familial Congenital Ectodermal Defects.Clinical, cosmetic and investigational dermatology · 2021Article
- Identification of Copy Number Variation Among Nonsyndromic Cleft Lip and or Without Cleft Palate With Hypodontia: A Genome-Wide Association Study.Frontiers in physiology · 2021Article
- Non-syndromic occurrence of true generalized microdontia with hypodontia: A case report.Medicine · 2019Article
- Orthodontic treatment of a non-syndromic patient with congenital agenesis of multiple permanent teeth: a rare case.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
- Research algorithm for the detection of genetic patterns and phenotypic variety of non-syndromic dental agenesis.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieObservational
- The prevalence of dental agenesis among children with cleft lip and palate patients in Lahore, Pakistan.Pakistan journal of medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTooth agenesis, the congenital absence of one or more teeth, can be diagnosed in children in the first decade of life. Tooth agenesis is a phenotypic feature of conditions such as ectodermal dysplasia, cleft lip, cleft palate, Down syndrome, and Van der Woude syndrome. Tooth agenesis can also be nonsyndromic. Studies have shown an association between the genetic determinants of nonsyndromic tooth agenesis and neoplasms in adulthood.
methodsThis review of the implications of tooth agenesis as a risk indicator for neoplasms in adulthood is based on a search of PubMed to identify published case series, case reports, and review articles. The reference articles were manually searched. The search was limited to articles published in the English language.
resultsNeoplasms reported in patients with tooth agenesis include colorectal neoplasms and epithelial ovarian cancer, as well as family histories of breast cancer, prostate cancer, and cancers of the brain and nervous system.
conclusionAlthough odontogenesis and tumorigenesis may seem to be unrelated processes, the clinical association between the two highlights the overlap of genetic determinants and molecular pathways. Tooth agenesis can be diagnosed during childhood and should be considered a marker for risk of neoplasms in adulthood. Healthcare providers should identify tooth agenesis and provide appropriate anticipatory guidance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.