Evidence map›Paper›PMID 30559575›Full record

ArticleComputational statistics & data analysis2019

Bayesian Functional Joint Models for Multivariate Longitudinal and Time-to-Event Data.

Kan Li, Sheng Luo

Abstract read
In one paragraph

Article in Computational statistics & data analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kan LiMerck Research Lab, Merck & Co, 351 North Sumneytown Pike, North Wales, PA 19454, USA.
Sheng LuoDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, 2400 Pratt St, 7040 North Pavilion, Durham, NC 27705, USA.
Duke Medical Center · USMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

Statistical Methods for Clinical Trials with Multivariate Longitudinal OutcomesR01NS091307 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LUO, SHENG · 2015 to 2018
$1.2M
NINDS NIH HHS R01 NS091307
6 · The paper itself

Abstract

A multivariate functional joint model framework is proposed which enables the repeatedly measured functional outcomes, scalar outcomes, and survival process to be modeled simultaneously while accounting for association among the multiple (functional and scalar) longitudinal and survival processes. This data structure is increasingly common across medical studies of neurodegenerative diseases and is exemplified by the motivating Alzheimer's Disease Neuroimaging Initiative (ADNI) study, in which serial brain imaging, clinical and neuropsychological assessments are collected to measure the progression of Alzheimer's disease (AD). The proposed functional joint model consists of a longitudinal function-on-scalar submodel, a regular longitudinal submodel, and a survival submodel which allows time-dependent functional and scalar covariates. A Bayesian approach is adopted for parameter estimation and a dynamic prediction framework is introduced for predicting the subjects' future health outcomes and risk of AD conversion. The proposed model is evaluated by a simulation study and is applied to the motivating ADNI study.

Indexed as

Alzheimer’s diseaseDynamic predictionJoint modelingLongitudinal functional data

Identifiers

PMID30559575
PMCPMC6294314
OpenAlexW2885740872

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.