ArticleIEEE journal of solid-state circuits2018
High-Density Redox Amplified Coulostatic Discharge-Based Biosensor Array.
Article in IEEE journal of solid-state circuits, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- A One-Step-Packaged CMOS/Microfluidics Wireless Bio-Analyzer for Point-of-Care Diagnostics.IEEE journal of solid-state circuits · 2025Article
- Improving engineered biological systems with electronics and microfluidics.Nature biotechnology · 2025Review
- Power management technologies for triboelectric nanogenerators.MRS bulletin · 2025Review
- CMOS Point-of-Care Diagnostics Technologies: Recent Advances and Future Prospects.Micromachines · 2024Review
- Towards Fully Integrated Portable Sensing Devices for COVID-19 and Future Global Hazards: Recent Advances, Challenges, and Prospects.Micromachines · 2021Review
- Applications of CMOS Devices for the Diagnosis and Control of Infectious Diseases.Micromachines · 2020Review
- Design and Analysis of a Sample-and-Hold CMOS Electrochemical Sensor for Aptamer-based Therapeutic Drug Monitoring.IEEE journal of solid-state circuits · 2020Article
- DNA Biosensor Based on Double-Layer Discharge for the Detection of HPV Type 16.Sensors (Basel, Switzerland) · 2019Article
- High-Density Redox Amplified Coulostatic Discharge-Based Biosensor Array.IEEE journal of solid-state circuits · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
High-density biosensor arrays are essential for many cutting-edge biomedical applications including point-of-care vaccination screening to detect multiple highly-contagious diseases. Typical electrochemical biosensing techniques are based on the measurement of sub-pA currents for micron-sized sensors requiring highly-sensitive readout circuits. Such circuits are often too complex to scale down for high-density arrays. In this paper, a high-density 4,096-pixel electrochemical biosensor array in 180 nm CMOS is presented. It uses a coulostatic discharge sensing technique and interdigitated electrode geometry to reduce both the complexity and size of the readout circuitry. Each biopixel contains an interdigitated microelectrode with a 13 aA low-leakage readout circuit directly underneath. Compared to standard planar electrodes, the implemented interdigitated electrodes achieve a maximum amplification factor of 10.5× from redox cycling. The array's sensor density is comparable to state-of-the-art arrays, all without augmenting the sensors with complex post-processing. The detection of anti-Rubella and anti-Mumps antibodies in human serum is demonstrated.
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Registered trials
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