ArticleNature neuroscience2019
Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop.
Erratum issuedAbstract read
In one paragraph
Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 97 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 1 pooled it
9.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
97 citing papers in PubMed, 1 synthesis or guideline pooled it, 177 citations in OpenAlex.
- Diffusion tensor imaging in detecting gliomas sub-regions of infiltration, local and remote recurrences: a systematic review.Neurosurgical review · 2024Pooled it
- Notch Overexpression Potentiates Interferon Signaling in Glioma Cells.Current issues in molecular biology · 2026Article
- Targeting SRC enhances differentiation and promotes multifaceted cell death mechanisms in recurrent group 3 medulloblastoma.Cell death & disease · 2026Article
- Notch1Scientific reports · 2026Article
- Extracellular matrix stiffness conditions glioblastoma cells for long-term migration: Mechanical memory as a driver of invasion and recurrence in glioblastoma.Neuro-oncology · 2026Review
- Progressive axonal degeneration in white matter pathways traversing peritumoral penumbra in frontotemporal glioma.Computational diffusion MRI. CDMRI (Workshop) · 2026Article
- Personalized chronotherapy in glioblastoma: integrating circadian profiling and PK-PD modelling to optimize temozolomide timing.NPJ precision oncology · 2025Article
- Par6/SOX2 interact to modulate stemness maintenance in glioma by regulating the EGFR/PI3K/AKT signaling cascade.Oncogene · 2025Article
- Cut the fat: targeting cholesterol and lipid metabolism in glioblastoma.Cell death & disease · 2025Review
- Single-cell transcriptomics of organoids reveals transcriptional control of germline stem cell fate by an E2F1-TFAP2C-SOX17 positive-feedback loop in Turner syndrome.Cell & bioscience · 2025Article
- Glioma-white matter tract interactions: A diffusion magnetic resonance imaging-based 3-tier classification and its clinical relevance.Neuro-oncology · 2025Article
- Phenotypic variations in glioma stem cells: regulatory mechanisms and implications for therapeutic strategies.Journal of translational medicine · 2025Review
- Decoding Glioblastoma Heterogeneity: Neuroimaging Meets Machine Learning.Neurosurgery · 2025Review
- USP18 deubiquitinates and stabilizes SOX9 to promote the stemness and malignant progression of glioblastoma.Cell death discovery · 2025Article
- Comparison ofClinical and translational radiation oncology · 2025Article
- Analysis of Neuronal Excitability Profiles for Motor-Eloquent Brain Tumor Entities Using nTMS in 800 Patients.Cancers · 2025Article
- Low-grade gliomas do not grow along white matter tracts: evidence from quantitative imaging.Brain communications · 2025Article
- Detecting glioblastoma infiltration beyond conventional imaging tumour margins using MTE-NODDI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Review
- Inside help for brain tumors: macrophage-mediated myelin recycling promotes cell state-specific glioblastoma progression.Signal transduction and targeted therapy · 2024Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
22 authors at 4 institutions in 1 country.
Jun Wang *Institute of Pathology and Southwest Cancer Center, Key Laboratory of the Ministry of Education, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Sen-Lin Xu *Institute of Pathology and Southwest Cancer Center, Key Laboratory of the Ministry of Education, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Jiang-Jie Duan *Institute of Pathology and Southwest Cancer Center, Key Laboratory of the Ministry of Education, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Liang Yi *Department of Neurosurgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Yu-Feng GuoInstitute of Pathology and Southwest Cancer Center, Key Laboratory of the Ministry of Education, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Yu ShiInstitute of Pathology and Southwest Cancer Center, Key Laboratory of the Ministry of Education, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Lin LiInstitute of Pathology and Southwest Cancer Center, Key Laboratory of the Ministry of Education, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Ze-Yu YangInstitute of Pathology and Southwest Cancer Center, Key Laboratory of the Ministry of Education, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Xue-Mei LiaoInstitute of Pathology and Southwest Cancer Center, Key Laboratory of the Ministry of Education, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Jiao CaiInstitute of Pathology and Southwest Cancer Center, Key Laboratory of the Ministry of Education, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Yan-Qi ZhangDepartment of Medical Statistics, Military Preventive Medicine Academy, Army Medical University (Third Military Medical University), Chongqing, China.
Hua-Liang XiaoDepartment of Pathology, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Li YinInstitute of Pathology and Southwest Cancer Center, Key Laboratory of the Ministry of Education, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Hao WuDepartment of Radiology, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Jing-Na ZhangDepartment of Medical Imaging, College of Biomedical Engineering, Army Medical University (Third Military Medical University), Chongqing, China.
Sheng-Qing LvDepartment of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Qing-Kai YangInstitute of Cancer Stem Cell, Cancer Center, Second Affiliated Hospital, Dalian Medical University, Dalian, China.ORCID http://orcid.org/0000-0001-6628-5393
Xiao-Jun YangCenter for Neuroscience, Medical College, Shantou University, Shantou, China.
Tao JiangDepartment of Neurosurgery, TianTan Hospital, Capital Medical University, Beijing, China.
Xia ZhangInstitute of Pathology and Southwest Cancer Center, Key Laboratory of the Ministry of Education, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Xiu-Wu BianInstitute of Pathology and Southwest Cancer Center, Key Laboratory of the Ministry of Education, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China. bianxiuwu@263.net.ORCID http://orcid.org/0000-0003-4383-0197
Shi-Cang YuInstitute of Pathology and Southwest Cancer Center, Key Laboratory of the Ministry of Education, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China. yushicang@163.com.ORCID http://orcid.org/0000-0001-6151-1224
Army Medical University · CNCapital Medical University · CNDalian Medical University · CNShantou University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early invasive growth along specific anatomical structures, especially the white matter tract, is regarded as one of the main causes of poor therapeutic outcome of people with gliomas. We show that some glioma stem cells (GSCs) are preferentially located along white matter tracts, which exhibit a demyelinated phenotype, at the invasive frontier of glioma tissues. These GSCs are CD133
Indexed as
Brain NeoplasmsCell Line, TumorDiffusion Tensor ImagingFeedback, PhysiologicalGliomaHumansJagged-1 ProteinNeoplasm InvasivenessNeoplastic Stem CellsReceptor, Notch1SOXB1 Transcription FactorsWhite MatterJagged-1 ProteinReceptor, Notch1SOXB1 Transcription Factors
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.