ArticleHypertension research : official journal of the Japanese Society of Hypertension2019
Age-differential association between serum uric acid and incident hypertension.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Relationship Between Elevated Serum Uric Acid and Risk of Stroke in Adult: An Updated and Dose-Response Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Serum Albumin and Uric Acid Levels Among Hypertensive Patients in Northwest Ethiopia: A Comparative Cross-Sectional Study.Health science reports · 2026Article
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- Article
- Consumption of fruits, vegetables, and nuts influences the association between serum uric acid and hypertension in Korean adults: A nationwide survey (KNHANES 2016-2021).Asia Pacific journal of clinical nutrition · 2025Article
- Bibliometric and visual assessment of research trends in the management of hyperuricemia (HUA).Clinical rheumatology · 2025Article
- Article
- High serum uric acid/creatinine ratio is a useful predictor of hypertension among Japanese community-dwelling persons.Clinical hypertension · 2025Article
- Gender Differences in the Associations Between Serum Urate and Cardiometabolic Risk Factors in Age-Matched Middle-Aged Japanese.Women's health reports (New Rochelle, N.Y.) · 2025Article
- Relationship between uric acid to HDL ratio and extent and severity of coronary artery disease.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2024Article
- Effects of uric acid on oxidative stress in vascular smooth muscle cells.Biomedical reports · 2024Article
- The role of uric acid in the risk of hypertension developed from prehypertension: a five-year Chinese urban cohort study.Archives of public health = Archives belges de sante publique · 2024Article
- Blood Lead Mediates the Relationship between Biological Aging and Hypertension: Based on the NHANES Database.Nutrients · 2024Article
- Associations of serum uric acid with cardiovascular disease risk factors: a retrospective cohort study in southeastern China.BMJ open · 2023Article
- Hyperuricemia is associated with more cardiometabolic risk factors in hypertensive younger Chinese adults than in elderly.Frontiers in cardiovascular medicine · 2023Article
- Association Between Uric Acid to HDL Cholesterol Ratio and Diabetic Complications in Men and Postmenopausal Women.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- The Ratio of Serum Uric Acid to Glycosylated Haemoglobin as a Predictor of All-Mortality in Elderly Patients with Diabetic Foot Ulcers: A Longitudinal Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Synergistic Interaction between Hyperuricemia and Abdominal Obesity as a Risk Factor for Metabolic Syndrome Components in Korean Population.Diabetes & metabolism journal · 2022Article
- The reality of treatment for hyperuricemia and gout in Japan: A historical cohort study using health insurance claims data.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Comorbidities of nontuberculous mycobacteria infection in Korean adults: results from the National Health Insurance Service-National Sample Cohort (NHIS-NSC) database.BMC pulmonary medicine · 2022Article
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Authors and funding
7 authors.
Funding
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Abstract
Increasing evidence suggests a positive association between the serum uric acid (SUA) level and incident hypertension. However, the association has been inconsistent based on age, sex, body mass index, and lipid profiles. Thus, we investigated whether there is an interaction between SUA and other risk factors on incident hypertension in the Korean general population. In this study, 808 participants aged 40-79 years were included. They were free of hypertension and major cardiovascular disease at baseline. Incident hypertension was defined as systolic blood pressure (SBP) ≥ 140 mmHg, diastolic blood pressure (DBP) ≥ 90 mmHg, or use of antihypertensive medication. To investigate whether the association between SUA and incident hypertension is modified by other risk factors for hypertension, a generalized linear model and Z test were used. During the mean follow-up of 3.3 years, 11.5% of men and 10.7% of women developed hypertension. The association between SUA and incident hypertension was inconsistent according to participant age (p for interaction = 0.009). The association between SUA level and incident hypertension was positively significant among people aged < 55 years (relative risk 1.74 per 1.0 mg/dL of SUA; p = 0.002), but there was no significant association among people aged ≥ 55 years (p = 0.894). In a secondary analysis, the SUA level was not associated with an increase in SBP, but positively associated with DBP. We observed an age-differential association between SUA level and incident hypertension among Koreans. An increased SUA level can be a trigger for hypertension through early vascular changes in the middle-aged population.
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