ArticleNature chemistry2019
Chemoselective methylene oxidation in aromatic molecules.
Article in Nature chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 128 citations in OpenAlex.
- Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides.Journal of peptide science : an official publication of the European Peptide Society · 2026Review
- Fluorinated Solvents for Chemoselective Oxidations: A Strategy toward Synthetic Ideality in Natural Product Synthesis.ACS organic & inorganic Au · 2026Article
- Manganese catalyzed oximation of hydrocarbons to oximes.Nature communications · 2026Article
- Article
- Catalytic Dioxygen Activation Using a Diketopiperazine and a Manganese Catalyst for Selective C(spJACS Au · 2025Article
- Polystyrene Upcycling via Photocatalytic and Non-Photocatalytic Degradation.Molecules (Basel, Switzerland) · 2025Review
- Cationic, Iodine(III)-Mediated and Directed Diastereoselective Oxidation of Inert C-H Bonds in Cyclic Hydrocarbons.Angewandte Chemie (International ed. in English) · 2025Article
- Chiral Bis-8-Aryl-isoquinoline Bis-alkylamine Iron Catalysts for Asymmetric Oxidation Reactions.Organic letters · 2025Article
- Oxoammonium-Catalyzed Oxidation ofJournal of the American Chemical Society · 2024Article
- Late-stage modification of bioactive compounds: Improving druggability through efficient molecular editing.Acta pharmaceutica Sinica. B · 2024Review
- A preparative small-molecule mimic of liver CYP450 enzymes in the aliphatic C-H oxidation of carbocyclicProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Research on the Mechanism of Low-Temperature Oxidation of Asphaltene.Molecules (Basel, Switzerland) · 2023Article
- Electro-Synthesis of Organic Compounds with Heterogeneous Catalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Strategy Evolution in a Skeletal Remodeling and C-H Functionalization-Based Synthesis of the Longiborneol Sesquiterpenoids.Journal of the American Chemical Society · 2022Article
- Chemoselective Oxyfunctionalization of Functionalized Benzylic Compounds with a Manganese Catalyst.Angewandte Chemie (International ed. in English) · 2022Article
- Radical C(sp3)-H functionalization and cross-coupling reactions.Nature reviews. Chemistry · 2022Article
- Amine Organocatalysis of Remote, Chemoselective C(spACS catalysis · 2022Article
- Total Synthesis and Late-Stage C-H Oxidations of ent-Trachylobane Natural Products.Angewandte Chemie (International ed. in English) · 2022Article
- Total Synthesis and Late-Stage C-H Oxidations ofAngewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2022Article
- Late-stage C-H functionalization offers new opportunities in drug discovery.Nature reviews. Chemistry · 2021Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Despite significant progress in the development of site-selective aliphatic C-H oxidations over the past decade, the ability to oxidize strong methylene C-H bonds in the presence of more oxidatively labile aromatic functionalities remains a major unsolved problem. Such chemoselective reactivity is highly desirable for enabling late-stage oxidative derivatizations of pharmaceuticals and medicinally important natural products that often contain such functionality. Here, we report a simple manganese small-molecule catalyst Mn(CF
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.