ArticleNature communications2018
Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- NEMP1 organizes the meiotic telomere-LINC interface to control chromosome movement and telomere integrity.bioRxiv : the preprint server for biology · 2026Article
- Meiotic telomeres of vole B chromosomes: shelterin and associated proteins provide a link to the nuclear envelope.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026Article
- ZCWPW1 organizes telomeric architecture to drive meiotic chromosome movements.bioRxiv : the preprint server for biology · 2026Article
- Molecular basis of XPF-ERCC1 targeting to SLX4-dependent DNA repair pathways.Nature communications · 2025Article
- Telomeres, the nuclear lamina, and membrane remodeling: Orchestrating meiotic chromosome movements.The Journal of cell biology · 2025Review
- Formation and resolution of meiotic chromosome entanglements and interlocks.Journal of cell science · 2024Review
- A report of two homozygous TERB1 protein-truncating variants in two unrelated women with primary infertility.Journal of assisted reproduction and genetics · 2024Article
- The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein.The Journal of cell biology · 2023Article
- Kinetic analysis of synaptonemal complex dynamics during meiosis of yeastFrontiers in cell and developmental biology · 2023Article
- Molecular insights into LINC complex architecture through the crystal structure of a luminal trimeric coiled-coil domain of SUN1.Frontiers in cell and developmental biology · 2023Article
- Homozygous missense mutation in CCDC155 disrupts the transmembrane distribution of CCDC155 and SUN1, resulting in non-obstructive azoospermia and premature ovarian insufficiency in humans.Human genetics · 2022Article
- Meiotic behavior, transmission and active genes of B chromosomes in the cichlid Astatotilapia latifasciata: new clues about nature, evolution and maintenance of accessory elements.Molecular genetics and genomics : MGG · 2022Article
- The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I.Cell reports · 2022Article
- Computational Analysis of the Potential Impact of MTC Complex Missenses SNPs Associated with Male Infertility.BioMed research international · 2022Article
- Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment.Nature communications · 2021Article
- The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.Nature communications · 2021Article
- Brain resilience across the general cognitive ability distribution: Evidence from structural connectivity.Brain structure & function · 2021Article
- Meiotic Chromosome Dynamics in Zebrafish.Frontiers in cell and developmental biology · 2021Review
- Disruption of human meiotic telomere complex genes TERB1, TERB2 and MAJIN in men with non-obstructive azoospermia.Human genetics · 2021Article
- The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans.BMC evolutionary biology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Meiotic chromosomes undergo rapid prophase movements, which are thought to facilitate the formation of inter-homologue recombination intermediates that underlie synapsis, crossing over and segregation. The meiotic telomere complex (MAJIN, TERB1, TERB2) tethers telomere ends to the nuclear envelope and transmits cytoskeletal forces via the LINC complex to drive these rapid movements. Here, we report the molecular architecture of the meiotic telomere complex through the crystal structure of MAJIN-TERB2, together with light and X-ray scattering studies of wider complexes. The MAJIN-TERB2 2:2 hetero-tetramer binds strongly to DNA and is tethered through long flexible linkers to the inner nuclear membrane and two TRF1-binding 1:1 TERB2-TERB1 complexes. Our complementary structured illumination microscopy studies and biochemical findings reveal a telomere attachment mechanism in which MAJIN-TERB2-TERB1 recruits telomere-bound TRF1, which is then displaced during pachytene, allowing MAJIN-TERB2-TERB1 to bind telomeric DNA and form a mature attachment plate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.