Evidence map›Paper›PMID 30559325›Full record

ArticleGenetics2019

Directional Selection Rather Than Functional Constraints Can Shape the G Matrix in Rapidly Adapting Asexuals.

Kevin Gomez, Jason Bertram, Joanna Masel

Abstract read
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Microbial population dynamics decouple growth response from environmental nutrient concentration.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kevin GomezGraduate Interdisciplinary Program in Applied Mathematics, University of Arizona, Tucson, Arizona 85721.
Jason BertramDepartment of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721.
Joanna MaselDepartment of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721 masel@email.arizona.edu.ORCID 0000-0002-7398-2127

Funding

Computational and Mathematical Modeling of Biomedical SystemsT32GM084905 · NIGMS · UNIVERSITY OF ARIZONA · PI SECOMB, TIMOTHY W. · 2009 to 2018
$2.2M
NIGMS NIH HHS T32 GM084905
6 · The paper itself

Abstract

Genetic covariances represent a combination of pleiotropy and linkage disequilibrium, shaped by the population's history. Observed genetic covariance is most often interpreted in pleiotropic terms. In particular, functional constraints restricting which phenotypes are physically possible can lead to a stable

Indexed as

Genetic FitnessHaploidyLife History TraitsModels, GeneticSelection, GeneticAdaptation, PhysiologicalEscherichia coliLinkage DisequilibriumPolymorphism, GeneticReproduction, AsexualSaccharomyces cerevisiaeclonal interferencelife history traitspolygenic adaptationstochastic processestrait correlations

Identifiers

PMID30559325
PMCPMC6366925

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.