Evidence map›Paper›PMID 30559322›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Duox1 Regulates Primary B Cell Function under the Influence of IL-4 through BCR-Mediated Generation of Hydrogen Peroxide.

Ryuichi Sugamata, Agnes Donko, Yousuke Murakami, Howard E Boudreau, Chen-Feng Qi, Jaeyul Kwon, Thomas L Leto

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Dual oxidase 1 is dispensable duringFrontiers in immunology · 2023
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ryuichi SugamataMolecular Defense Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892; and.ORCID 0000-0002-7204-4702
Agnes DonkoMolecular Defense Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892; and.
Yousuke MurakamiLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852; and.
Howard E BoudreauMolecular Defense Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892; and.
Chen-Feng QiLaboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852; and.
Jaeyul KwonMolecular Defense Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892; and.ORCID 0000-0002-2452-4111
Thomas L LetoMolecular Defense Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892; and tleto@nih.gov.ORCID 0000-0002-5463-1583
National Institutes of Health · US

Funding

Role of Reactive Oxygen Species in Lymphocyte Development and FunctionZIAAI001060 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LETO, THOMAS · 2009 to 2024
$3.3M
Intramural NIH HHS ZIA AI001060
6 · The paper itself

Abstract

Engagement of the BCR with Ags triggers signaling pathways for commitment of B lymphocyte responses that can be regulated, in part, by reactive oxygen species. To investigate the functional relevance of reactive oxygen species produced in primary B cells, we focused on the role of the hydrogen peroxide generator Duox1 in stimulated splenic B cells under the influence of the T

Indexed as

AnimalsAntigens, CD19B-LymphocytesCell ProliferationCells, CulturedDual OxidasesGerminal CenterHydrogen PeroxideImmunoglobulin Class SwitchingInterleukin-4MiceMice, Inbred C57BLMice, KnockoutReactive Oxygen SpeciesReceptors, Antigen, B-CellSignal TransductionAntigens, CD19Dual OxidasesHydrogen PeroxideInterleukin-4Reactive Oxygen SpeciesReceptors, Antigen, B-Cell

Identifiers

PMID30559322
PMCPMC6324942
OpenAlexW2905062429

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.