Evidence map›Paper›PMID 30559307›Full record

ArticleMolecular and cellular biology2019

G-Alpha Subunit Abundance and Activity Differentially Regulate β-Catenin Signaling.

Arshiya Banu, Karen J Liu, Alistair J Lax, Agamemnon E Grigoriadis

Open access · hybridAbstract read
In one paragraph

Article in Molecular and cellular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. In Vivo Targets ofInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Arshiya BanuDepartment of Microbiology, King's College London, Guy's Hospital, London, United Kingdom.
Karen J LiuCentre for Craniofacial and Regenerative Biology, King's College London, Guy's Hospital, London, United Kingdom.ORCID 0000-0002-2483-2165
Alistair J LaxDepartment of Microbiology, King's College London, Guy's Hospital, London, United Kingdom alistair.lax@kcl.ac.uk agi.grigoriadis@kcl.ac.uk.
Agamemnon E GrigoriadisCentre for Craniofacial and Regenerative Biology, King's College London, Guy's Hospital, London, United Kingdom alistair.lax@kcl.ac.uk agi.grigoriadis@kcl.ac.uk.ORCID 0000-0002-5941-8132
Guy's Hospital · GB

Funding

Biotechnology and Biological Sciences Research Council BB/E013872/1Biotechnology and Biological Sciences Research Council BB/R015953/1
6 · The paper itself

Abstract

Heterotrimeric G proteins are signal transduction proteins involved in regulating numerous signaling events. In particular, previous studies have demonstrated a role for G-proteins in regulating β-catenin signaling. However, the link between G-proteins and β-catenin signaling is controversial and appears to depend on G-protein specificity. We describe a detailed analysis of a link between specific G-alpha subunits and β-catenin using G-alpha subunit genetic knockout and knockdown approaches. The

Indexed as

AnimalsBacterial ProteinsBacterial Toxinsbeta CateninFibroblastsGene Expression RegulationGTP-Binding Protein alpha SubunitsGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding ProteinsHEK293 CellsHeterotrimeric GTP-Binding ProteinsHumansMiceSignal TransductionBacterial ProteinsBacterial Toxinsbeta CateninGTP-Binding Protein alpha SubunitsGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding ProteinsHeterotrimeric GTP-Binding ProteinsPasteurella multocida toxinG-alpha subunitsG-proteins, Pasteurella multocida toxinβ-catenin

Identifiers

PMID30559307
PMCPMC6379582
OpenAlexW2903813138

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.