Evidence map›Paper›PMID 30559246›Full record

ArticleJournal of cell science2019

Contractility kits promote assembly of the mechanoresponsive cytoskeletal network.

Priyanka Kothari, Vasudha Srivastava, Vasudha Aggarwal, Irina Tchernyshyov, Jennifer E Van Eyk, Taekjip Ha, Douglas N Robinson

Abstract read
In one paragraph

Article in Journal of cell science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Queue Gaps Among the IQGAPs inInternational journal of molecular sciences · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Proteomic Analysis of Dictyostelium discoideum by Mass Spectrometry.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  8. Article
  9. Article
  10. Non-muscle myosin 2 filaments are processive in cells.bioRxiv : the preprint server for biology · 2023
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. The mechanobiome: a goldmine for cancer therapeutics.American journal of physiology. Cell physiology · 2021
    Review
  17. The Unusual Suspects in Cytokinesis: Fitting the Pieces Together.Frontiers in cell and developmental biology · 2020
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Priyanka KothariDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Vasudha SrivastavaDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Vasudha AggarwalDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-9856-1292
Irina TchernyshyovDepartment of Medicine, The Smidt Heart Institute and Advanced Clinical Biosystems Institute, Cedar-Sinai Medical Center, Los Angeles, CA 90048, USA.
Jennifer E Van EykDepartment of Medicine, The Smidt Heart Institute and Advanced Clinical Biosystems Institute, Cedar-Sinai Medical Center, Los Angeles, CA 90048, USA.
Taekjip HaDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Douglas N RobinsonDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA dnr@jhmi.edu.ORCID 0000-0003-1236-4891

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
The Biochemical Basis for the Mechanics of CytokinesisR01GM066817 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROBINSON, DOUGLAS N · 2003 to 2025
$7.3M
Zeiss LSM780 Confocal Microscope for a Core FacilityS10OD016374 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2013 to 2013
$584k
Single-Molecule Dissection of mTOR ComplexesR21AG042332 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CHEN, JIE, HA, TAEKJIP · 2013 to 2014
$361k
Positive and negative regulation of the cytokinesis contractility controllerF31GM122258 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KOTHARI, PRIYANKA · 2018 to 2019
$72k
Howard Hughes Medical InstituteNIA NIH HHS R21 AG042332NIGMS NIH HHS F31 GM122258NIGMS NIH HHS R01 GM066817NIGMS NIH HHS T32 GM007445NIH HHS S10 OD016374
6 · The paper itself

Abstract

Cellular contractility is governed by a control system of proteins that integrates internal and external cues to drive diverse shape change processes. This contractility controller includes myosin II motors, actin crosslinkers and protein scaffolds, which exhibit robust and cooperative mechanoaccumulation. However, the biochemical interactions and feedback mechanisms that drive the controller remain unknown. Here, we use a proteomics approach to identify direct interactors of two key nodes of the contractility controller in the social amoeba

Indexed as

ActinsCytoskeletonDictyosteliumMicrofilament ProteinsMyosin Type IIProtozoan ProteinsActinsctxA protein, Dictyostelium discoideumMicrofilament ProteinsMyosin Type IIProtozoan ProteinsCortexillin IFCCSIQGAPLC-MSMyosin IISiMPull

Identifiers

PMID30559246
PMCPMC6362397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.