Evidence map›Paper›PMID 30559209›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Structural determinants driving homoserine lactone ligand selection in the

Amelia R McCready, Jon E Paczkowski, Brad R Henke, Bonnie L Bassler

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. MrtR ofProceedings of the National Academy of Sciences of the United States of America · 2026
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  3. Review
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  6. Review
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  8. Disclosing New Insights on Pyrazolo[3,4-Journal of microbiology and biotechnology · 2025
    Article
  9. Article
  10. Article
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  15. Article
  16. Characterization of natural product inhibitors of quorum sensing inbioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amelia R McCreadyDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544.
Jon E PaczkowskiDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544.
Brad R HenkeOpti-Mol Consulting, LLC, Cary, NC 27513.
Bonnie L BasslerDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544; bbassler@princeton.edu.ORCID 0000-0002-0043-746X

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Intra-and Inter-Species Communication in BacteriaR01GM065859 · NIGMS · PRINCETON UNIVERSITY · PI BASSLER, BONNIE L · 2002 to 2015
$4.2M
Intra- and Inter- Species Communication in BacteriaR37GM065859 · NIGMS · PRINCETON UNIVERSITY · PI BASSLER, BONNIE L · 2016 to 2025
$3.4M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM065859NIGMS NIH HHS R37 GM065859NIGMS NIH HHS T32 GM007388
6 · The paper itself

Abstract

Quorum sensing is a cell-cell communication process that bacteria use to orchestrate group behaviors. Quorum sensing is mediated by signal molecules called autoinducers. Autoinducers are often structurally similar, raising questions concerning how bacteria distinguish among them. Here, we use the

Indexed as

Quorum Sensing4-ButyrolactoneBacterial ProteinsBlotting, WesternLigandsMutagenesis, Site-DirectedProtein Structure, QuaternaryPseudomonas aeruginosaStructure-Activity RelationshipTrans-Activators4-ButyrolactoneBacterial Proteinshomoserine lactoneLasR protein, Pseudomonas aeruginosaLigandsTrans-Activatorscrystal structurehomoserine lactoneLasRPseudomonas aeruginosaquorum sensing

Identifiers

PMID30559209
PMCPMC6320529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.