Evidence map›Paper›PMID 30559191›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis.

Ernest Duah, Lakshminarayan Reddy Teegala, Vinay Kondeti, Ravi K Adapala, Venkateshwar G Keshamouni, Yoshihide Kanaoka, K Frank Austen, Charles K Thodeti, Sailaja Paruchuri

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 84 citations in OpenAlex.

  1. Autocrine CysLTOncogene · 2026
    Article
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  6. TSLP: contrasting roles in cancer.Frontiers in immunology · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Human Lung Mast Cells: Therapeutic Implications in Asthma.International journal of molecular sciences · 2022
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Ernest DuahDepartment of Chemistry, University of Akron, Akron, OH 44325.
Lakshminarayan Reddy TeegalaDepartment of Chemistry, University of Akron, Akron, OH 44325.
Vinay KondetiDepartment of Chemistry, University of Akron, Akron, OH 44325.
Ravi K AdapalaDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272.
Venkateshwar G KeshamouniDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
Yoshihide KanaokaDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115.
K Frank AustenDivision of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115; fausten@research.bwh.harvard.edu sp97@uakron.edu.
Charles K ThodetiDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272.
Sailaja ParuchuriDepartment of Chemistry, University of Akron, Akron, OH 44325; fausten@research.bwh.harvard.edu sp97@uakron.edu.
University of Akron · USHarvard University · USNortheast Ohio Medical University · USUniversity of Michigan–Ann Arbor · US

Funding

Mechanotransduction in myocardial adaptation to ischemiaR01HL119705 · NHLBI · NORTHEAST OHIO MEDICAL UNIVERSITY · PI THODETI, CHARLES K · 2015 to 2018
$1.5M
Integration of Mechanical and Soluble Signaling in Tumor AngiogenesisR15CA202847 · NCI · NORTHEAST OHIO MEDICAL UNIVERSITY · PI THODETI, CHARLES K · 2016 to 2016
$453k
Post-Infarction Remodeling in the Diabetic MyocardiumR15HL106442 · NHLBI · NORTHEAST OHIO MEDICAL UNIVERSITY · PI MESZAROS, J GARY, THODETI, CHARLES K · 2012 to 2012
$444k
NCI NIH HHS R15 CA202847NHLBI NIH HHS R01 HL119705NHLBI NIH HHS R15 HL106442
6 · The paper itself

Abstract

Cysteinyl leukotrienes (cys-LTs) are proinflammatory mediators that enhance vascular permeability through distinct receptors (CysLTRs). We found that CysLT

Indexed as

AnimalsCapillary PermeabilityCyclohexanecarboxylic AcidsEndothelial CellsGene Knockout TechniquesLeukotriene AntagonistsLung NeoplasmsMaleMiceMice, Inbred C57BLNeoplasm MetastasisNeoplasms, ExperimentalNeoplasm TransplantationNeovascularization, PathologicPhthalic AcidsReceptors, Leukotriene3-(((3-carboxycyclohexyl)amino)carbonyl)-4-(3-(4-(4-phenoxybutoxy)phenyl)propoxy)benzoic acidCyclohexanecarboxylic Acidscysteinyl leukotriene receptor 2Leukotriene AntagonistsPhthalic AcidsReceptors, Leukotrieneangiogenesiscysteinyl leukotriene receptorsendothelial cellsmetastasistumor growth

Identifiers

PMID30559191
PMCPMC6320507
OpenAlexW2904452165

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.