Evidence map›Paper›PMID 30559180›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

p47 licenses activation of the immune deficiency pathway in the tick

Erin E McClure Carroll, Xiaowei Wang, Dana K Shaw, Anya J O'Neal, Adela S Oliva Chávez, Lindsey J Brown, Vishant Mahendra Boradia, Holly L Hammond, Joao H F Pedra

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 41 citations in OpenAlex.

  1. ATF6 enables pathogen infection in ticks by inducingProceedings of the National Academy of Sciences of the United States of America · 2025
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  5. Review
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  13. Croquemort elicits activation of the immune deficiency pathway in ticks.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Integrative analysis highlights molecular and immune responses of tickFrontiers in cellular and infection microbiology · 2023
    Article
  15. Frontiers in immunology · 2023
    Article
  16. Life (Basel, Switzerland) · 2022
    Article
  17. Article
  18. Article
  19. The Impact of RNA Interference in Tick Research.Pathogens (Basel, Switzerland) · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Erin E McClure CarrollDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
Xiaowei WangDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
Dana K ShawDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
Anya J O'NealDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
Adela S Oliva ChávezDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
Lindsey J BrownDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
Vishant Mahendra BoradiaDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
Holly L HammondDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201.
Joao H F PedraDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201 jpedra@som.umaryland.edu.
University of Maryland, Baltimore · US

Funding

Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Jonathan D Oliver · 2018 to 2026
$13.5M
Development of Paratransgenic Ticks for Disease ControlR01AI049424 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MUNDERLOH, ULRIKE GERTRUD · 2002 to 2022
$6.9M
Ubiquitylation and Rickettsial Colonization of a Tick VectorR01AI116523 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2016 to 2025
$6.2M
Characterization of an E3 Ubiquitin Ligase Substrate in the Tick Immune Deficiency PathwayF31AI138440 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI MCCLURE, ERIN E. · 2018 to 2019
$48k
NIAID NIH HHS F31 AI138440NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI049424NIAID NIH HHS R01 AI116523
6 · The paper itself

Abstract

The E3 ubiquitin ligase X-linked inhibitor of apoptosis (XIAP) acts as a molecular rheostat for the immune deficiency (IMD) pathway of the tick

Indexed as

Adaptor Proteins, Signal TransducingAnaplasmaAnimalsArthropod ProteinsBorrelia burgdorferiDrosophilaGene Knockout TechniquesIxodesNF-kappa BProtein DomainsX-Linked Inhibitor of Apoptosis ProteinAdaptor Proteins, Signal TransducingArthropod ProteinsNF-kappa BX-Linked Inhibitor of Apoptosis ProteinIMD pathwayLyme diseaserickettsial infectionsticksubiquitin ligase

Identifiers

PMID30559180
PMCPMC6320499
OpenAlexW2905535835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.