Evidence map›Paper›PMID 30559148›Full record

ArticleCancer research2019

Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk.

Yaohua Yang, Lang Wu, Xiang Shu, Yingchang Lu, Xiao-Ou Shu, Qiuyin Cai, Alicia Beeghly-Fadiel, Bingshan Li, Fei Ye, Andrew Berchuck and 90 more

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Genetic effects on the skin methylome in healthy older twins.American journal of human genetics · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Genetic Regulation of DNA Methylation Yields Novel Discoveries in GWAS of Colorectal Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
    Article
  16. Fixing the GAP: The role of RhoGAPs in cancer.European journal of cell biology · 2022
    Review
  17. Observational
  18. Integrating Genome and Methylome Data to Identify Candidate DNA Methylation Biomarkers for Pancreatic Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
  19. An integrative multiomics analysis identifies putative causal genes for COVID-19 severity.Genetics in medicine : official journal of the American College of Medical Genetics · 2021
    Article
  20. OCaMIR-A Noninvasive, Diagnostic Signature for Early-Stage Ovarian Cancer: A Multi-cohort Retrospective and Prospective Study.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

100 authors at 20 institutions in 20 countries.

Yaohua YangDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Lang WuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Xiang ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0002-4129-9403
Yingchang LuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0002-4129-9403
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Alicia Beeghly-FadielDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Bingshan LiDepartment of Molecular Physiology & Biophysics, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee.
Fei YeDivision of Cancer Biostatistics, Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
Andrew BerchuckDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina.
Hoda Anton-CulverDepartment of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, California.
Susana BanerjeeGynaecology Unit, Royal Marsden Hospital, London, United Kingdom.
Javier BenitezHuman Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Line BjørgeDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
James D BrentonCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-5738-6683
Ralf ButzowDepartment of Pathology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Ian G CampbellPeter MacCallum Cancer Center, Melbourne, Victoria, Australia.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-8919-1971
Kexin ChenDepartment of Epidemiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Linda S CookUniversity of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, New Mexico.
Daniel W CramerDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Anna deFazioCentre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0003-0057-4744
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-4591-1214
Jennifer A DohertyHuntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Diana M EcclesCancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Digna Velez EdwardsVanderbilt Epidemiology Center, Vanderbilt Genetics Institute, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee.
Peter A FaschingDavid Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California.ORCID 0000-0003-4885-8471
Renée T FortnerDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-1426-8505
Simon A GaytherThe Center for Bioinformatics and Functional Genomics at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Graham G GilesCancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.ORCID 0000-0003-4946-9099
Rosalind M GlasspoolThe Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.
Ellen L GoodeDepartment of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota.
Marc T GoodmanSamuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center, Los Angeles, California.
Jacek GronwaldDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Holly R HarrisProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0002-2572-6727
Florian HeitzDepartment of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany.
Michelle A HildebrandtDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Estrid HøgdallDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Claus K HøgdallThe Juliane Marie Centre, Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
David G HuntsmanDepartment of Molecular Oncology, BC Cancer Research Centre, Vancouver, British Columbia, Canada.
Siddhartha P KarCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Beth Y KarlanWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Linda E KelemenHollings Cancer Center and Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina.
Lambertus A KiemeneyRadboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0002-2368-1326
Susanne K KjaerDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.ORCID 0000-0002-8347-1398
Anita KoushikCHUM Research Centre (CRCHUM) and Département de Médicine Sociale et Préventive, Université de Montréal, Montréal, Quebec, Canada.ORCID 0000-0001-5304-7660
Diether LambrechtsVIB Center for Cancer Biology, VIB and Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium.
Nhu D LeCancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada.
Douglas A LevineGynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Leon F MassugerDepartment of Gynaecology, Radboud Institute for Molecular Life sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
Keitaro MatsuoDivision of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
Taymaa MayDivision of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, Toronto, Ontario, Canada.
Iain A McNeishDepartment Surgery & Cancer, Imperial College London, London, United Kingdom.ORCID 0000-0002-9387-7586
Usha MenonMRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London, London, United Kingdom.ORCID 0000-0003-3708-1732
Francesmary ModugnoWomens Cancer Research Center, Magee-Womens Research Institute and Hillman Cancer Center, Pittsburgh, Pennsylvania.
Alvaro N MonteiroDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.ORCID 0000-0002-8448-4801
Patricia G MoormanDepartment of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina.
Kirsten B MoysichDivision of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York.
Roberta B NessSchool of Public Health, University of Texas Health Science Center at Houston (UTHealth), Houston, Texas.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-0916-2976
Håkan OlssonDepartment of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.
N Charlotte Onland-MoretJulius Center for Health Sciences and Primary Care, University Utrecht, UMC Utrecht, Utrecht, the Netherlands.
Sue K ParkDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.ORCID 0000-0001-5002-9707
James PaulThe Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.ORCID 0000-0001-7367-5816
Celeste L PearceDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan.
Tanja PejovicDepartment of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon.
Catherine M PhelanDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
Malcolm C PikeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.
Susan J RamusSchool of Women's and Children's Health, Faculty of Medicine, University of New South Wales Sydney, Sydney, New South Wales, Australia.ORCID 0000-0003-0005-7798
Elio RiboliImperial College London, London, United Kingdom.
Cristina Rodriguez-AntonaHuman Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.ORCID 0000-0001-8750-7338
Isabelle RomieuNutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), Lyon, France.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina.ORCID 0000-0002-6776-0018
Joellen M SchildkrautDepartment of Public Health Sciences, University of Virginia, Charlottesville, Virginia.
Veronica W SetiawanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Kang ShanDepartment of Obstetrics and Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.
Nadeem SiddiquiDepartment of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, United Kingdom.
Weiva SiehDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Meir J StampferChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Rebecca SutphenEpidemiology Center, College of Medicine, University of South Florida, Tampa, Florida.
Anthony J SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
Lukasz M SzafronDepartment of Immunology, Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland.ORCID 0000-0003-1670-0274
Soo Hwang TeoCancer Research Malaysia, Subang Jaya, Selangor, Malaysia.ORCID 0000-0002-0444-590X
Shelley S TworogerDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.ORCID 0000-0002-6986-7046
Jonathan P TyrerCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
Penelope M WebbPopulation Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0003-0733-5930
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Emily WhiteFred Hutchinson Cancer Research Center, Seattle, Washington.
Walter C WillettDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7387-6845
Yin Ling WooDepartment of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Li YanDepartment of Molecular Biology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.
Drakoulis YannoukakosMolecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos", Athens, Greece.
Georgia Chenevix-TrenchDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Thomas A SellersDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
Paul D P PharoahCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee. jirong.long@vumc.org.
Vanderbilt University Medical Center · USCancer Research UK Cambridge Center · GBUniversity of Southern California · USBeatson West of Scotland Cancer Centre · GBBrigham and Women's Hospital · USCedars-Sinai Medical Center · USMoffitt Cancer Center · USBC Cancer Agency · CADuke University · USHebei Medical University · CNQIMR Berghofer Medical Research Institute · AURadboud University Nijmegen · NLSpanish National Cancer Research Centre · ESUniversity Malaya Medical Centre · MYUniversity of Copenhagen · DKUniversity of Helsinki · FIUniversity of Washington · USAichi Cancer Center · JPAlberta Health Services · CABreast Cancer Now · GB

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5M
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI ELLEN L. GOODE · 2009 to 2026
$37.0M
Cancer Research UK 10119Cancer Research UK 10124Cancer Research UK 14136Cancer Research UK 15973Cancer Research UK 16561Cancer Research UK C1312/A15589Cancer Research UK C490/A6187Cancer Research UK C536/A13086Cancer Research UK C536/A6689Cancer Research UK C570/A16491Cancer Research UK C8221/A19170Department of HealthIntramural NIH HHS Z01 ES044005Intramural NIH HHS Z01 ES049033Medical Research Council 1000143Medical Research Council G0401527Medical Research Council G0501974Medical Research Council G0601891Medical Research Council G1000143Medical Research Council MR/M012190/1Medical Research Council MR/N003284/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR000445NCI NIH HHS K05 CA154337NCI NIH HHS K07 CA080668NCI NIH HHS K07 CA095666NCI NIH HHS K22 CA138563NCI NIH HHS N01 CN025403NCI NIH HHS N01 PC067010NCI NIH HHS P01 CA017054NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA072720NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA105009NCI NIH HHS P50 CA136393NCI NIH HHS P50 CA159981NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA054419NCI NIH HHS R01 CA058598NCI NIH HHS R01 CA058860NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA063678NCI NIH HHS R01 CA063682NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA074850NCI NIH HHS R01 CA076016NCI NIH HHS R01 CA080742NCI NIH HHS R01 CA083918NCI NIH HHS R01 CA087538NCI NIH HHS R01 CA095023NCI NIH HHS R01 CA106414NCI NIH HHS R01 CA112523NCI NIH HHS R01 CA122443NCI NIH HHS R01 CA126841NCI NIH HHS R01 CA142081NCI NIH HHS R01 CA149429NCI NIH HHS R01 CA160669NCI NIH HHS R03 CA113148NCI NIH HHS R03 CA115195NCI NIH HHS R37 CA054281NCI NIH HHS R37 CA070867NCI NIH HHS U01 CA058860NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA069417NCI NIH HHS U01 CA164973NCI NIH HHS U19 CA148112NCI NIH HHS UM1 CA164973NCI NIH HHS UM1 CA176726NCI NIH HHS UM1 CA186107NCRR NIH HHS S10 RR025141Wellcome TrustWellcome Trust 076113World Health Organization 001
6 · The paper itself

Abstract

DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark of cancer. However, the role of DNA methylation in epithelial ovarian cancer (EOC) remains unclear. In this study, high-density genetic and DNA methylation data in white blood cells from the Framingham Heart Study (

Indexed as

DNA MethylationBiomarkers, TumorCarcinoma, Ovarian EpithelialCohort StudiesFemaleGenetic Predisposition to DiseaseHumansModels, GeneticOvarian NeoplasmsPredictive Value of TestsRiskWhite PeopleWomen's HealthBiomarkers, Tumor

Identifiers

PMID30559148
PMCPMC6359948
OpenAlexW2905141927

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.