Observational studyThe British journal of general practice : the journal of the Royal College of General Practitioners2019
Nausea and vomiting of pregnancy and resource implications: the NVP Impact Study.
Observational study in The British journal of general practice : the journal of the Royal College of General Practitioners, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Non-pharmaceutical Chinese Medical Therapies for Nausea and Vomiting of Pregnancy: An Umbrella Review of Systematic Reviews and Meta-analyses of Randomized Controlled Trials.Chinese journal of integrative medicine · 2026Pooled it
- Acupuncture for nausea and vomiting during pregnancy: an overview of systematic reviews.Frontiers in endocrinology · 2026Pooled it
- What are the costs associated with nausea and vomiting in pregnancy and hyperemesis gravidarum? A systematic review.BMC pregnancy and childbirth · 2025Pooled it
- The Australian MotherSafe enhanced service for nausea and vomiting in pregnancy and hyperemesis gravidarum: a mixed methods study.BMC pregnancy and childbirth · 2026Article
- Advancing the women's health strategy: a policy lab aimed at improving effective management of hyperemesis gravidarum.Health research policy and systems · 2025Article
- The impact and management of hyperemesis gravidarum: Current and future perspectives.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Review
- How are hospitals in England, Scotland and Wales caring for women with nausea and vomiting in pregnancy: a national service evaluation.BMC health services research · 2025Article
- Interventions Initiated Before and After Pregnancy for Women who Experience Severe Nausea and Vomiting of Pregnancy: A Scoping Review.Maternal and child health journal · 2025Article
- Assessing the approaches to nausea and vomiting in pregnancy: insights from a nationwide survey of Italian gynecologists (PURITY light).Frontiers in medicine · 2025Article
- Nausea and Vomiting of Pregnancy and its Management with the Dual-Release Formulation of Doxylamine and Pyridoxine.Geburtshilfe und Frauenheilkunde · 2024Article
- Bioavailability of CaribanDrugs in R&D · 2023Article
- Self-reported vomiting during pregnancy in North-east Nigeria: perceptions, prevalence, severity and impacts.BMC pregnancy and childbirth · 2022Article
- Anti-emetic effects of thalidomide: Evidence, mechanism of action, and future directions.Current research in pharmacology and drug discovery · 2022Review
- Nausea and vomiting in pregnancy is not just 'morning sickness': data from a prospective cohort study in the UK.The British journal of general practice : the journal of the Royal College of General Practitioners · 2020Article
- The chance of recurrence of hyperemesis gravidarum: A systematic review.European journal of obstetrics & gynecology and reproductive biology: X · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNausea and vomiting of pregnancy (NVP) is the most prevalent medical condition associated with pregnancy. The Royal College of Obstetricians and Gynaecologists published its first guidelines for management of NVP in 2016, although many current treatments are off label, with only one recently licensed treatment for NVP in the UK.
aimTo identify the current practices for NVP management across the patient pathway, and estimate the economic burden to NHS services. DESIGN AND
settingThis was an observational, retrospective research study conducted in the Newcastle Gateshead Clinical Commissioning Group (CCG) health economy area in England.
methodData were collected from GP practices, local hospital datasets, ambulance services (April 2013-March 2016), and the Hospital Episode Statistics dataset (2006-2016).
resultsEight GP practices participated in the study. In all, 15.2% of the total pregnant population presented with NVP. Treatment varied significantly between GP practices, and 33.6% of women re-presented to their GP. There was an annual increase in women admitted to hospital for NVP symptoms, with increasing length of stay per admission. Almost half (44.6%) of the calls to 999/111 from women experiencing NVP symptoms resulted in an ambulance dispatch. The annual cost of NVP to this health economy was estimated to be £199 804, which crudely extrapolates to £25 758 731 at UK level. Due to underestimations of costs, the impact to the UK NHS could be up to £62 373 961.
conclusionThere is considerable variation in current management practices for NVP outside of recently published guidelines, and this may result in substantial resource use and avoidable financial impact to the NHS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.