ArticleBMC infectious diseases2018
Endogenous endophthalmitis caused by a multidrug-resistant hypervirulent Klebsiella pneumoniae strain belonging to a novel single locus variant of ST23: first case report in China.
Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- A review of bloodstream infections-pathogens, pathogenesis, diagnostic strategies, treatment methods-challenges and future aspects.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Review
- Review
- Hypervirulent and Drug-ResistantInternational journal of general medicine · 2026Review
- Determination of the prevalence of hypervirulent Klebsiella pneumoniae strains in Northeast Iran, Mashhad.Scientific reports · 2025Article
- HypervirulentPharmaceuticals (Basel, Switzerland) · 2025Review
- Identification of Antimicrobial Resistance Patterns, Type VI Secretion System, and Virulence Factors in Clinical Isolates ofInternational journal of microbiology · 2025Article
- Clinical features, treatment and prognosis of patients with endogenous infectious endophthalmitis.International ophthalmology · 2024Review
- A mini case report:Heliyon · 2024Article
- HypervirulentPathogens & immunity · 2024Review
- Identification of hypervirulent Klebsiella pneumoniae based on biomarkers and Galleria mellonella infection model.BMC microbiology · 2023Article
- Pyogenic liver abscess caused by extended-spectrum β-lactamase-producing hypervirulentThe Journal of international medical research · 2023Review
- A rare case of concomitantAnnals of medicine and surgery (2012) · 2023Article
- Gram-Negative Endogenous Endophthalmitis: A Systematic Review.Microorganisms · 2022Review
- Performance of the AIDRScreening system in detecting diabetic retinopathy in the fundus photographs of Chinese patients: a prospective, multicenter, clinical study.Annals of translational medicine · 2022Article
- The Role of Plasmid and Resistance Gene Acquisition in the Emergence of ST23 Multi-Drug Resistant, Hypervirulent Klebsiella pneumoniae.Microbiology spectrum · 2022Article
- The invasiveJournal of Taibah University Medical Sciences · 2022Article
- Beta-lactamase determinants and molecular typing of carbapenem-resistant classic and hypervirulentFrontiers in microbiology · 2022Article
- Fatal disseminated pyogenic infection due to hypermucoviscous hypervirulent Klebsiella pneumoniae: A case report and literature review.Clinical case reports · 2021Article
- HypervirulentLife (Basel, Switzerland) · 2021Review
- Clinical Challenges with HypervirulentJournal of translational internal medicine · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEndogenous endophthalmitis caused by hypervirulent Klebsiella pneumoniae (HVKP) is an emerging infectious disease commonly with a devastating visual outcome. Most HVKP strains display a wild-type susceptibility profile to antibiotics. However, reports of antimicrobial-resistant HVKP have increased over time, which poses a serious therapeutic dilemma. CASE PRESENTATION: A 25-year-old man with a liver abscess and poorly controlled diabetes mellitus was admitted for endophthalmitis due to K. pneumoniae. The isolate displayed hypermucoviscosity as determined by a positive string test and exhibited resistance to ceftazidime, piperacillin-tazobactam and amikacin. Whole genome sequencing (WGS) analysis demonstrated the isolate to be a K1-serotype strain and belong to a novel single locus variant of ST23, ST2922. In addition to the virulence genes linked to HVKP, rmpA, magA, iucABCDiutA (aerobactin), ybtAPSTUX (yersiniabactin) and iroBDN (salmochelin), it was found to harbor extended-spectrum β-lactamase (ESBL) gene (bla
conclusionsThis is the first known case of endogenous endophthalmitis caused by a multidrug-resistant HVKP strain ever reported in China. Early diagnosis and treatment with intravenous and intravitreal injection of carbapenem were essential for a favorable visual outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.