Evidence map›Paper›PMID 30558547›Full record

ArticleBMC gastroenterology2018

Lower expression of endogenous intestinal alkaline phosphatase may predict worse prognosis in patients with Crohn's disease.

Seon-Young Park, Ji-Young Kim, Su-Mi Lee, Jin Ook Chung, Ji-Ho Seo, SunMin Kim, Dong Hyun Kim, Chang-Hwan Park, Jae-Kyun Ju, Young-Eun Joo and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. The Relationship Between Obesity and Intestinal Alkaline Phosphatase: A Clinical and Biochemical Study.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026
    Article
  2. Article
  3. Review
  4. Inflammatory bowel disease biomarkers.Medicinal research reviews · 2022
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Seon-Young ParkDivision of Gastroenterology and Hepatology, Chonnam National University Medical School, Gwangju, South Korea.
Ji-Young KimDivision of Gastroenterology and Hepatology, Chonnam National University Medical School, Gwangju, South Korea.
Su-Mi LeeDivision of Gastroenterology and Hepatology, Chonnam National University Medical School, Gwangju, South Korea.
Jin Ook ChungDivision of Endocrinology and Metabolism, Chonnam National University Medical School, Gwangju, South Korea.
Ji-Ho SeoDivision of Gastroenterology and Hepatology, Chonnam National University Medical School, Gwangju, South Korea.
SunMin KimDivision of Gastroenterology and Hepatology, Chonnam National University Medical School, Gwangju, South Korea.
Dong Hyun KimDivision of Gastroenterology and Hepatology, Chonnam National University Medical School, Gwangju, South Korea.
Chang-Hwan ParkDivision of Gastroenterology and Hepatology, Chonnam National University Medical School, Gwangju, South Korea.
Jae-Kyun JuDepartment of Surgery, Chonnam National University Medical School, Gwangju, South Korea.
Young-Eun JooDivision of Gastroenterology and Hepatology, Chonnam National University Medical School, Gwangju, South Korea.
Jae-Hyuk LeeDepartment of Pathology, Chonnam National University Medical School, Gwangju, South Korea.
Hyun-Soo KimDivision of Gastroenterology and Hepatology, Chonnam National University Medical School, Gwangju, South Korea. hskim@chonnam.ac.kr.
Sung-Kyu ChoiDivision of Gastroenterology and Hepatology, Chonnam National University Medical School, Gwangju, South Korea.
Jong-Sun RewDivision of Gastroenterology and Hepatology, Chonnam National University Medical School, Gwangju, South Korea.
Chonnam National University Hospital · KRChonnam National University · KR

Funding

Chonnam National University Hospital Research Institute of Clinical Medicine CRI 14011-1
6 · The paper itself

Abstract

backgroundsIntestinal alkaline phosphatase (IAP) plays important role in gut homeostasis. We aimed to evaluate the expression of endogenous IAP and to assess the clinical course according to the expression of endogenous IAP in patients with Crohn's disease (CD).

methodsA total of 32 consecutive patients (14 males) with CD were included in the study. We measured the level of endogenous iAP in inflamed and noninflamed colonic mucosa. To verify the inflammation status, we measured the level of mRNA for IL-6, TNF-α, and TLR-4. We monitored the clinical courses of patients during follow-up after acquisition of biopsy specimens.

resultsMedian age of patients was 22.5 years (range, 15-49). Median CD activity index (CDAI, range) was 93.7 (22.8~ 154.9). There were colonic involvements in all patients and perianal involvement in 43.8% patients. The mRNA levels of IL-6 (p = 0.005) and TLR-4 (p = 0.013) in inflamed mucosa were significantly higher than those in non-inflamed mucosa. However, there was no difference of expression of TNF-α mRNA (p = 0.345). During a 14-month follow-up (range, 9 months-54 months), there were 19 patients with clinical recurrences. There were 9 patients (9/19, 47.4%) with IAP expression ratio (inflamed to non-inflamed) ≤ 1.0 in patients with clinical recurrence while there was one patient (1/13, 7.7%) with IAP ratio ≤ 1.0 in patients without clinical recurrence (p = 0.024).

conclusionLower expression of IAP in inflamed mucosa compared to non-inflamed mucosa may be associated with clinical recurrence in patients with CD.

Indexed as

AdolescentAdultAlkaline PhosphataseColonCrohn DiseaseFemaleGene ExpressionHumansIntestinal MucosaMaleMiddle AgedPrognosisReceptors, Interleukin-6RNA, MessengerToll-Like Receptor 4Tumor Necrosis Factor-alphaAlkaline PhosphataseIL6R protein, humanReceptors, Interleukin-6RNA, MessengerTLR4 protein, humanTNF protein, humanToll-Like Receptor 4Tumor Necrosis Factor-alphaCrohn’s diseaseInflammationRecurrence

Identifiers

PMID30558547
PMCPMC6296121
OpenAlexW2904306451

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.