ArticleCirculation. Cardiovascular imaging2018
First-in-Human Studies of [
Article in Circulation. Cardiovascular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02385877 (Clinical Translation of 18F-Labeled Hydroxyphenethylguanidines for Quantification of Regional Cardiac Sympathetic Nerve Density With PET), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Translation of 18F-Labeled Hydroxyphenethylguanidines for Quantification of Regional Cardiac Sympathetic Nerve Density With PET
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Modified Reaction Conditions for the Radiosynthesis ofACS medicinal chemistry letters · 2026Article
- PET imaging of cardiac sympathetic nervous system dysfunction using meta-[European journal of nuclear medicine and molecular imaging · 2026Article
- Novel F-18-labeled Tracers of Sympathetic Function for Improved Risk Stratification and Clinical Outcomes.Current cardiology reports · 2025Review
- 3-[Journal of the Endocrine Society · 2024Article
- Navigating new horizons: Prospects of NET-targeted radiopharmaceuticals in precision medicine.Theranostics · 2024Review
- Detection of sympathetic denervation defects in Fabry disease by hybrid [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Rationalizing the Binding Modes of PET Radiotracers Targeting the Norepinephrine Transporter.Pharmaceutics · 2023Article
- PET imaging of metastatic paraganglioma using novel 3-[European journal of nuclear medicine and molecular imaging · 2022Article
- Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Review
- Quantifying radiotracer activity on cardiac sympathetic imaging: Does it really matter?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Prototype device for endoventricular beta-emitting radiotracer detection and molecularly-guided intervention.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Molecular Imaging-Derived Biomarker of Cardiac Nerve Integrity - Introducing High NET Affinity PET ProbeTheranostics · 2022Article
- Nerve regeneration in transplanted organs and tracer imaging studies: A review.Frontiers in bioengineering and biotechnology · 2022Review
- Quantifying cardiac sympathetic denervation: first studies ofEuropean journal of nuclear medicine and molecular imaging · 2022Article
- Dynamic planar scintigraphy for the rapid kinetic measurement of myocardialEJNMMI research · 2021Article
- Does lipid-lowering medication improve cardiac sympathetic nerve integrity?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Fully Automated Radiosynthesis of [ACS medicinal chemistry letters · 2020Article
- Use of 55 PET radiotracers under approval of a Radioactive Drug Research Committee (RDRC).EJNMMI radiopharmacy and chemistry · 2020Article
- Recent advances in radiotracers targeting norepinephrine transporter: structural development and radiolabeling improvements.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundDisease-induced damage to cardiac autonomic nerve populations is associated with an increased risk of sudden cardiac death. The extent of cardiac sympathetic denervation, assessed using planar scintigraphy or positron emission tomography, has been shown to predict the risk of arrhythmic events in heart failure patients staged for implantable cardioverter defibrillator therapy. The goal of this study was to perform first-in-human evaluations of 4-[ METHODS AND
resultsCardiac positron emission tomography studies with 4-[
conclusions4-[ CLINICAL
trial registrationURL: https://www.clinicaltrials.gov . Unique identifier: NCT02385877.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.