Evidence map›Paper›PMID 30558441›Full record

ArticleAmerican journal of Alzheimer's disease and other dementias2019

High Risk of Suicide in Behavioral Variant Frontotemporal Dementia.

Milena Zucca, Elisa Rubino, Alessandro Vacca, Flora Govone, Annalisa Gai, Paola De Martino, Silvia Boschi, Salvatore Gentile, Maria Teresa Giordana, Innocenzo Rainero

Open access · bronzeAbstract read
In one paragraph

Article in American journal of Alzheimer's disease and other dementias, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Depression and apathy in frontotemporal dementia: a short assessment of facts and outlook.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Living with dementia: Why I am thinking of 'death'.Dementia (London, England) · 2023
    Article
  8. Article
  9. Suicide risk in first year after dementia diagnosis in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Frontotemporal Dementia and Suicide; Could Genetics be a Key Factor?American journal of Alzheimer's disease and other dementias
    Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Milena Zucca1 Department of Neuroscience "Rita Levi Montalcini," Aging Brain and Memory Clinic, University of Torino, Torino, Italy.ORCID 0000-0001-6383-5548
Elisa Rubino1 Department of Neuroscience "Rita Levi Montalcini," Aging Brain and Memory Clinic, University of Torino, Torino, Italy.
Alessandro Vacca1 Department of Neuroscience "Rita Levi Montalcini," Aging Brain and Memory Clinic, University of Torino, Torino, Italy.
Flora Govone1 Department of Neuroscience "Rita Levi Montalcini," Aging Brain and Memory Clinic, University of Torino, Torino, Italy.
Annalisa Gai1 Department of Neuroscience "Rita Levi Montalcini," Aging Brain and Memory Clinic, University of Torino, Torino, Italy.
Paola De Martino1 Department of Neuroscience "Rita Levi Montalcini," Aging Brain and Memory Clinic, University of Torino, Torino, Italy.
Silvia Boschi1 Department of Neuroscience "Rita Levi Montalcini," Aging Brain and Memory Clinic, University of Torino, Torino, Italy.
Salvatore Gentile1 Department of Neuroscience "Rita Levi Montalcini," Aging Brain and Memory Clinic, University of Torino, Torino, Italy.
Maria Teresa Giordana1 Department of Neuroscience "Rita Levi Montalcini," Aging Brain and Memory Clinic, University of Torino, Torino, Italy.
Innocenzo Rainero1 Department of Neuroscience "Rita Levi Montalcini," Aging Brain and Memory Clinic, University of Torino, Torino, Italy.
University of Turin · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe purpose of the study was to determine the prevalence of suicidal ideation and attempts in patients with behavioral variant frontotemporal dementia (bvFTD), evaluating possible risk factors for suicidality.

methodsRisk of suicide was assessed using the Scale for Suicide Ideation (SSI) in 35 patients with bvFTD and 25 controls.

resultsAccording to SSI, 40% of patients with bvFTD had suicidal ideation in comparison to 8% of controls ( P = .009). Four patients with bvFTD have attempted suicide versus none control ( P = .006). Patients with bvFTD with suicide risk showed higher levels of anxiety, depression, stress, and hopelessness than patients without suicide risk ( P < .001). Patients who attempted suicide were younger and had a longer disease duration than those with only suicide ideation. Intriguingly, 40% of patients with parkinsonism presented high level of suicide ideation.

conclusionsOur findings show that patients with bvFTD have a high risk of suicide. Additional studies in larger populations are needed to confirm our results.

Indexed as

Suicidal IdeationAgedAnxietyDepressionFemaleFrontotemporal DementiaHumansMalePrevalencePsychiatric Status Rating ScalesRisk FactorsbvFTDfrontotemporal dementiaFTDparkinsonismSSIsuicide

Identifiers

PMID30558441
PMCPMC10852495
OpenAlexW2905201367

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.