Evidence map›Paper›PMID 30558369›Full record

ArticleNanomaterials (Basel, Switzerland)2018

A Gemini Cationic Lipid with Histidine Residues as a Novel Lipid-Based Gene Nanocarrier: A Biophysical and Biochemical Study.

María Martínez-Negro, Laura Blanco-Fernández, Paolo M Tentori, Lourdes Pérez, Aurora Pinazo, Conchita Tros de Ilarduya, Emilio Aicart, Elena Junquera

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

María Martínez-NegroGrupo de Química Coloidal y Supramolecular, Departamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain. mmnegro@ucm.es.ORCID 0000-0002-9358-4425
Laura Blanco-FernándezDepartamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain. lblancof@unav.es.ORCID 0000-0002-1859-0884
Paolo M TentoriGrupo de Química Coloidal y Supramolecular, Departamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain. paolo.tentori@sns.it.ORCID 0000-0003-3539-0523
Lourdes PérezDpto. Tecnología Química y Tensioactivos, IQAC-CSIC, 08034 Barcelona, Spain. lpmste@cid.csic.es.ORCID 0000-0002-3696-021X
Aurora PinazoDpto. Tecnología Química y Tensioactivos, IQAC-CSIC, 08034 Barcelona, Spain. apgste@cid.csic.es.ORCID 0000-0002-5955-322X
Conchita Tros de IlarduyaDepartamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain. ctros@unav.es.ORCID 0000-0001-6414-2719
Emilio AicartGrupo de Química Coloidal y Supramolecular, Departamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain. aicart@ucm.es.ORCID 0000-0003-1654-4136
Elena JunqueraGrupo de Química Coloidal y Supramolecular, Departamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain. junquera@ucm.es.ORCID 0000-0002-0655-5782
Universidad Complutense de Madrid · ESInstitute of Advanced Chemistry of Catalonia · ESNavarre Institute of Health Research · ES

Funding

Ministerio de Ciencia e Innovación CTQ2015-65972-R, CTQ2017-88948-P, CTQ2015-64425-C2-2-R)Universidad Complutense de Madrid UCMA05-33-010
6 · The paper itself

Abstract

This work reports the synthesis of a novel gemini cationic lipid that incorporates two histidine-type head groups (C₃(C

Indexed as

biophysical characterizationcell viabilitygemini cationic lipid with histidine residuesgene deliverylipid-based gene nanocarrierplasmid DNAstransfection

Identifiers

PMID30558369
PMCPMC6316511
OpenAlexW2905005753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.