Evidence map›Paper›PMID 30558366›Full record

ArticlePharmaceutics2018

Potentially Inappropriate Prescribing of Oral Solid Medications in Elderly Dysphagic Patients.

Matteo Sestili, Serena Logrippo, Marco Cespi, Giulia Bonacucina, Letizia Ferrara, Silvia Busco, Iolanda Grappasonni, Giovanni Filippo Palmieri, Roberta Ganzetti, Paolo Blasi

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Matteo SestiliHospital Pharmacy, Italian National Research Center on Aging (INRCA), via della Montagnola 81, 60127 Ancona, Italy. matteo.sestili@sanita.marche.it.
Serena LogrippoSchool of Pharmacy, University of Camerino, via Gentile III da Varano, 62032 Camerino, Italy. serena.logrippo@unicam.it.ORCID 0000-0001-5514-8043
Marco CespiSchool of Pharmacy, University of Camerino, via Gentile III da Varano, 62032 Camerino, Italy. marco.cespi@unicam.it.ORCID 0000-0001-6916-7915
Giulia BonacucinaSchool of Pharmacy, University of Camerino, via Gentile III da Varano, 62032 Camerino, Italy. giulia.bonacucina@unicam.it.
Letizia FerraraMedical Direction, Italian National Research Center on Aging (INRCA), via della Montagnola 81, 60127 Ancona, Italy. l.ferrara@inrca.it.
Silvia BuscoSchool of Pharmacy, University of Camerino, via Gentile III da Varano, 62032 Camerino, Italy. silvia.busco@studenti.unicam.it.
Iolanda GrappasonniSchool of Pharmacy, University of Camerino, via Gentile III da Varano, 62032 Camerino, Italy. iolanda.grappasonni@unicam.it.
Giovanni Filippo PalmieriSchool of Pharmacy, University of Camerino, via Gentile III da Varano, 62032 Camerino, Italy. gianfilippo.palmieri@unicam.it.ORCID 0000-0002-5349-4978
Roberta GanzettiHospital Pharmacy, Italian National Research Center on Aging (INRCA), via della Montagnola 81, 60127 Ancona, Italy. r.ganzetti@inrca.it.
Paolo BlasiSchool of Pharmacy, University of Camerino, via Gentile III da Varano, 62032 Camerino, Italy. paolo.blasi@unicam.it.ORCID 0000-0002-8543-4275
Università di Camerino · ITIstituto Nazionale di Riposo e Cura per Anziani · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pharmaceutical formulations suitable for dysphagic patients are not always commercially available, motivating caregivers to crush tablets or open capsules to facilitate swallowing. Since this action may modify the characteristics of the medicine, it should be considered potentially inappropriate. This paper is the first to focus on how hospitalization affected the rate of potentially inappropriate prescriptions (PIPs) and the incidence of dosage form-related PIPs in elderly patients with dysphagia. Data was collected by reviewing patient medical records in the Italian National Research Center on Aging of Ancona. The therapy at admission and discharge was analysed in terms of: inappropriate drug associations, inappropriate drugs for dysphagic patients, inappropriate dosage forms and inappropriate dosage form modifications. Forty-one dysphagic patients with an average age of 88.3 years were included in the study and 451 prescriptions were analysed. PIPs were widespread at admission, and hospitalization did not improve the situation in a statistically significant manner. The most common PIPs identified (>80%) were related to dosage form selection and modification. This study highlights a clear need for continuing medical education about prescription appropriateness and modification of solid dosage forms in patients with dysphagia.

Indexed as

capsulescompoundinginappropriate prescriptionsmanipulationold-old patientssolid oral dosage formtablets

Identifiers

PMID30558366
PMCPMC6321461
OpenAlexW2904240661

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.