Evidence map›Paper›PMID 30558306›Full record

ArticleNutrients2018

Per-Arnt-Sim Kinase (PASK) Deficiency Increases Cellular Respiration on a Standard Diet and Decreases Liver Triglyceride Accumulation on a Western High-Fat High-Sugar Diet.

Jenny A Pape, Colleen R Newey, Haley R Burrell, Audrey Workman, Katelyn Perry, Benjamin T Bikman, Laura C Bridgewater, Julianne H Grose

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Advances in Research on Diabetes by Human Nutriomics.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jenny A PapeDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA. jennyapattison@gmail.com.
Colleen R NeweyDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA. colleennewey@byu.edu.
Haley R BurrellDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA. haley.burrell@gmail.com.
Audrey WorkmanDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA. workm050@umn.edu.ORCID 0000-0003-0186-8111
Katelyn PerryDepartment of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA. kate.perry22@gmail.com.
Benjamin T BikmanDepartment of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA. benjamin_bikman@byu.edu.
Laura C BridgewaterDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA. laura_bridgewater@byu.edu.
Julianne H GroseDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA. julianne_grose@byu.edu.ORCID 0000-0001-8816-6635
Brigham Young University · US

Funding

Regulation and Function of PAS Kinase - PASsing glucose to control respiration, lipogenesis and cell cycleR15GM100376 · NIGMS · BRIGHAM YOUNG UNIVERSITY · PI GROSE, JULIANNE H. · 2012 to 2022
$1.3M
National Institutes of Health R15 GM100376-01NIGMS NIH HHS R15 GM100376
6 · The paper itself

Abstract

Diabetes and the related disease metabolic syndrome are epidemic in the United States, in part due to a shift in diet and decrease in physical exercise. PAS kinase is a sensory protein kinase associated with many of the phenotypes of these diseases, including hepatic triglyceride accumulation and metabolic dysregulation in male mice placed on a high-fat diet. Herein we provide the first characterization of the effects of western diet (high-fat high-sugar, HFHS) on Per-Arnt-Sim kinase mice (PASK

Indexed as

Cell RespirationDiet, WesternAnimalsAryl Hydrocarbon Receptor Nuclear TranslocatorBasic Helix-Loop-Helix ProteinsDiabetes MellitusDietDietary FatsDietary SugarsDiet, High-FatFemaleGenotypeLiverMaleMice, Inbred C57BLMice, KnockoutArnt protein, mouseAryl Hydrocarbon Receptor Nuclear TranslocatorBasic Helix-Loop-Helix ProteinsDietary FatsDietary SugarsPAS domain kinasesProtein Serine-Threonine KinasesRepressor ProteinsSim1 protein, mouseTriglycerideselectron transport chainfemalehepatichigh-fat high-sugar dietlipidomicslipidslivermicePASKPAS kinaserespirationsexual dimorphismtriglycerideswestern diet

Identifiers

PMID30558306
PMCPMC6316003
OpenAlexW2903674457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.