Evidence map›Paper›PMID 30558297›Full record

ArticleMarine drugs2018

Antiviral and Antioxidant Properties of Echinochrome A.

Sergey A Fedoreyev, Natalia V Krylova, Natalia P Mishchenko, Elena A Vasileva, Evgeny A Pislyagin, Olga V Iunikhina, Vyacheslav F Lavrov, Oksana A Svitich, Linna K Ebralidze, Galina N Leonova

Abstract read
In one paragraph

Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Review
  2. Antidiabetic Potential of Sea UrchinCurrent issues in molecular biology · 2025
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  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
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  12. Article
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  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sergey A FedoreyevG.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok 690022, Russia. fedoreev-s@mail.ru.
Natalia V KrylovaG.P. Somov Institute of Epidemiology and Microbiology, FEB RAS, Vladivostok 690087, Russia. krylovanatalya@gmail.com.ORCID 0000-0002-9048-6803
Natalia P MishchenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok 690022, Russia. mischenkonp@mail.ru.
Elena A VasilevaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok 690022, Russia. vasilieva_el_an@mail.ru.
Evgeny A PislyaginG.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok 690022, Russia. pislyagin@hotmail.com.ORCID 0000-0002-3558-0821
Olga V IunikhinaG.P. Somov Institute of Epidemiology and Microbiology, FEB RAS, Vladivostok 690087, Russia. olga_iun@inbox.ru.ORCID 0000-0002-6723-582X
Vyacheslav F LavrovI.I. Mechnikov Research Institute of Vaccines and Sera, Moscow 105064, Russia. v.f.lavrov@inbox.ru.
Oksana A SvitichI.I. Mechnikov Research Institute of Vaccines and Sera, Moscow 105064, Russia. svitichoa@yandex.ru.
Linna K EbralidzeI.I. Mechnikov Research Institute of Vaccines and Sera, Moscow 105064, Russia. lina.lidze@gmail.com.
Galina N LeonovaG.P. Somov Institute of Epidemiology and Microbiology, FEB RAS, Vladivostok 690087, Russia. galinaleon41@gmail.com.

Funding

Ministry of Education and Science of the Russian Federation RFMEF161317X0076
6 · The paper itself

Abstract

The aim of this study was to examine the in vitro antioxidant and antiviral activities of echinochrome A and echinochrome-based antioxidant composition against tick-borne encephalitis virus (TBEV) and herpes simplex virus type 1 (HSV-1). The antioxidant composition, which is a mixture of echinochrome A, ascorbic acid, and α-tocopherol (5:5:1), showed higher antioxidant and antiviral effects than echinochrome A. We suppose that echinochrome A and its composition can both directly affect virus particles and indirectly enhance antioxidant defense mechanisms in the hosting cell. The obtained results allow considering the echinochrome A and the composition of antioxidants on its basis as the promising agents with the both antioxidant and antiviral activities.

Indexed as

alpha-TocopherolAnimalsAntioxidantsAntiviral AgentsAscorbic AcidBiological ProductsChlorocebus aethiopsDrug CombinationsEncephalitis Viruses, Tick-BorneHerpesvirus 1, HumanLipid PeroxidationNaphthoquinonesReactive Oxygen SpeciesSea UrchinsVero Cellsalpha-TocopherolAntioxidantsAntiviral AgentsAscorbic AcidBiological ProductsDrug Combinationsechinochrome ANaphthoquinonesReactive Oxygen Speciesantioxidant activityantiviral activitycomposition of antioxidantsechinochrome A

Identifiers

PMID30558297
PMCPMC6315383

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.