ReviewJournal of clinical medicine2018
Fetal Toxicity of Immunosuppressive Drugs in Pregnancy.
Review in Journal of clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Psychological Experiences of Pregnancy Following Transplantation: A Systematic Qualitative Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Maternal and perinatal outcomes of live births after uterus transplantation: A systematic review.Acta obstetricia et gynecologica Scandinavica · 2025Pooled it
- Brazilian Thoracic Association recommendations for the management of lymphangioleiomyomatosis.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025Guideline
- Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of gynecologic cancer.Journal for immunotherapy of cancer · 2023Guideline
- Pregnancy Outcomes After Belatacept Exposure in Solid Organ Transplant Recipients: A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- New-Onset ANCA-Associated Vasculitis in Pregnancy Successfully Treated With Rituximab: A Case Report and Literature Review.Kidney medicine · 2026Article
- Behavioural and physiological impacts of varying doses of methotrexate on Drosophila melanogaster.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- A review of immunosuppressive therapy in the context of uterine VCA and pregnancy.Frontiers in transplantation · 2026Review
- Safety profiles of cyclosporine and tacrolimus in pregnancy: a pharmacovigilance analysis using the FDA Adverse Event Reporting System.Frontiers in medicine · 2026Article
- Advanced stage melanoma during pregnancy: recommendations from a retrospective, multicentre, registry-based study.EClinicalMedicine · 2025Article
- Observational
- Kidney disease and reproductive health.Nature reviews. Nephrology · 2025Review
- Past, Present, and Future: A Review of Uterus Transplant.Transplant international : official journal of the European Society for Organ Transplantation · 2025Review
- Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women.Frontiers in pharmacology · 2025Article
- Alloimmune Causes of Recurrent Pregnancy Loss: Cellular Mechanisms and Overview of Therapeutic Approaches.Medicina (Kaunas, Lithuania) · 2024Review
- Impact of Systemic Lupus Erythematosus on Conception: Insights into Infertility, Fertility Preservation, Assisted Reproductive Technology, and Pregnancy Outcomes.Seminars in reproductive medicine · 2024Review
- Pregnancy after heart and kidney transplantation: a case report.JHLT open · 2024Article
- Successful pregnancy after cyclophosphamide therapy for systemic lupus erythematosus: a case report.Annals of medicine and surgery (2012) · 2024Article
- Healthcare provider recognition of pregnancy related risks and management considerations in patients with tuberous sclerosis complex.Orphanet journal of rare diseases · 2024Article
- A Case Report of Metastatic Gastric Cancer Treated with Pembrolizumab during Pregnancy.Fetal diagnosis and therapy · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Women affected by autoimmune diseases, organ transplantation, or neoplasia need to continue immunosuppressive treatment during pregnancy. In this setting, not only a careful planning of pregnancy, but also the choice of drugs is critical to preventing maternal complications and minimizing the fetal risks. Some immunosuppressive drugs are teratogenic and should be replaced even before the pregnancy, while other drugs need to be managed with caution to prevent fetal risks, including miscarriage, intrauterine growth restriction, prematurity, and low birth weight. In particular, the increasing use of biologic agents raises the question of their compatibility with reproduction. In this review we present data on the indication and safety in pregnancy of the most frequently used immunosuppressive drugs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.