Evidence map›Paper›PMID 30558277›Full record

ArticleMolecules (Basel, Switzerland)2018

Deuterated Arachidonic Acids Library for Regulation of Inflammation and Controlled Synthesis of Eicosanoids: An In Vitro Study.

Dmitry V Chistyakov, Ivan S Filimonov, Nadezhda V Azbukina, Sergei V Goriainov, Viktor V Chistyakov, Maksim A Fomich, Andrei V Bekish, Vadim V Shmanai, Marina G Sergeeva, Mikhail S Shchepinov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Dmitry V ChistyakovBelozersky Institute of Physico-Chemical Biology, Moscow State University, 119992 Moscow, Russia. chistyakof@gmail.com.ORCID 0000-0003-0137-8585
Ivan S FilimonovAll-Russian Research Institute for Optophysical Measurements (VNIIOFI), Ozernaya 46, 119361 Moscow, Russia. fis82@yandex.ru.
Nadezhda V AzbukinaFaculty of Bioengineering and Bioinformatics, Moscow Lomonosov State University, 119234 Moscow, Russia. ridernadya@gmail.com.ORCID 0000-0002-2546-2418
Sergei V GoriainovSREC PFUR, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia. goryainovs@list.ru.
Viktor V ChistyakovSREC PFUR, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia. chistvic@gmail.com.
Maksim A FomichInstitute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Surganova Str 13, 220072 Minsk, Belarus. mfomich@gmail.com.ORCID 0000-0001-6174-794X
Andrei V BekishInstitute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Surganova Str 13, 220072 Minsk, Belarus. andreibekish@yahoo.com.
Vadim V ShmanaiInstitute of Physical Organic Chemistry, National Academy of Sciences of Belarus, Surganova Str 13, 220072 Minsk, Belarus. v.shmanai@gmail.com.ORCID 0000-0003-1775-8101
Marina G SergeevaBelozersky Institute of Physico-Chemical Biology, Moscow State University, 119992 Moscow, Russia. mg.sergeeva@gmail.com.
Mikhail S ShchepinovRetrotope, Incorporated, 4300 El Camino Real, Suite 201, Los Altos, CA 94022, USA. misha@retrotope.com.
Lomonosov Moscow State University · RUNational Academy of Sciences of Belarus · BYPeoples' Friendship University of Russia · RUAll-Russian Research Institute for Optical and Physical Measurements · RURetrotope (United States) · US

Funding

Program 5-100 RUDN UniversityRussian Science Foundation 16-15-10298
6 · The paper itself

Abstract

The synthesis of signal lipids, including eicosanoids, is not fully understood, although it is key to the modulation of various inflammatory states. Recently, isotopologues of essential polyunsaturated fatty acids (PUFAs) deuterated at bis-allylic positions (D-PUFAs) have been proposed as inhibitors of non-enzymatic lipid peroxidation (LPO) in various disease models. Arachidonic acid (AA, 20:4 n-6) is the main precursor to several classes of eicosanoids, which are produced by cyclooxygenases (COX) and lipoxygenases (LOX). In this study we analyzed the relative activity of human recombinant enzymes COX-2, 5-LOX, and 15-LOX-2 using a library of arachidonic acids variably deuterated at the bis-allylic (C7, C10, and C13) positions. Kinetic parameters (KM, V

Indexed as

Arachidonate 15-LipoxygenaseArachidonic AcidsCyclooxygenase 2DeuteriumHumansHydroxyeicosatetraenoic AcidsInflammationKinetics5-hydroxy-6,8,11,14-eicosatetraenoic acid8-hydroxyeicosatetraenoic acidArachidonate 15-LipoxygenaseArachidonic AcidsCyclooxygenase 2DeuteriumHydroxyeicosatetraenoic Acidsdeuterated arachidonic acidseicosanoidshuman 15-lipoxygenase-2human 5-lipoxygenasehuman cyclooxygenase 2isotope effect

Identifiers

PMID30558277
PMCPMC6321560
OpenAlexW2904754652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.