Observational studyMedicine2018
Acupuncture for gender differences and similarities in cerebral activity of health volunteers: A pilot fMRI study.
Observational study in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Effects of acupuncture on cartilage p38MAPK and mitochondrial pathways in animal model of knee osteoarthritis: A systematic evaluation and meta-analysis.Frontiers in neuroscience · 2022Pooled it
- Sex differences in brain functional connectivity changes to different energy densities of laser acupuncture at PC6 (Neiguan): a pilot resting-state fMRI study.Lasers in medical science · 2026Trial
- Acupuncture modulates the microbiota-gut-brain axis: a novel therapeutic strategy for amnestic mild cognitive impairment.Frontiers in neuroscience · 2025Article
- Gender differences in brain activity underlying acupuncture sensations at LR3: a task-based fMRI study.Frontiers in human neuroscience · 2025Article
- Anatomical Exploration of the KI1 Acupoint: Implications for Medial and Lateral Plantar Nerve Stimulation.Medicina (Kaunas, Lithuania) · 2024Article
- Gender Differences in Amplitude of Low-Frequency Fluctuation Alterations in Healthy Volunteers by Acupuncture on Left "LI 15": A Resting-State fMRI Study.Behavioural neurology · 2024Article
- Gender-Related Issues in the Management of Low-Back Pain: A Current Concepts Review.Clinics and practice · 2023Review
- Increased low frequency fluctuation in the brain after acupuncture treatment in CSVDCI patients: A randomized control trial study.Frontiers in neuroscience · 2023Article
- Efficacy of Acupuncture Treatment for Incidence of Poststroke Comorbidities: A Systematic Review and Meta-Analysis of Nationalized Cohort Studies.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- A protocol of systematic review and meta-analysis of acupuncture for drug resistant epilepsy.Medicine · 2020Article
- Transcranial Direct Current Stimulation Over Prefrontal Areas Improves Psychomotor Inhibition State in Patients With Traumatic Brain Injury: A Pilot Study.Frontiers in neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to explore the feasible gender differences and similarities in cerebral activity response to the acupuncture at local acupoints around knee.Fifteen male and 15 female healthy adults were recruited and included in this study. Functional magnetic resonance imaging (fMRI) was applied to measure cerebral activity response to acupuncture at Liangqiu (ST34), Xuehai (SP-10), Neixiyan (EX-LE4), and Dubi (ST-35).Acupuncture activated the postcentral gyrus, precuneus, temporal, posterior lobe, and occipital lobe in both males and females. When compared with females, males showed brain activation in the right middle frontal gyrus, inferior frontal gyrus, right precuneus, right superior parietal lobule, left cerebellum anterior lobe; and brain deactivation in the right frontal. When compared with males, females were observed brain activation in the right frontal lobe, right parietal lobe, and right middle temporal gyrus; and brain deactivation in the left and right medial frontal gyrus.The results of this study demonstrated that the neural effects of local acupoints around knee might be different between male and female subjects. Further clinical trials should take this gender effect into account in their design of studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.