Observational studyMedicine2018
Biochemical clinical factors associated with missed abortion independent of maternal age: A retrospective study of 795 cases with missed abortion and 694 cases with normal pregnancy.
Observational study in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- The Predictive Significance of Platelet-to-Lymphocyte Ratio for Miscarriage: A Systematic Review and Meta-Analysis.Immunity, inflammation and disease · 2025Pooled it
- Comparison of first trimester complete blood count parameters in missed abortion and healthy pregnant women: a retrospective case-control study.BMC pregnancy and childbirth · 2026Article
- Clinical significance of plasma SERPINA3 in patients with missed miscarriage.Frontiers in medicine · 2026Article
- Uterine artery hemodynamic parameters as key predictors of missed abortion risk: clinical validation based on a multimodal predictive model.American journal of translational research · 2026Article
- Efficacy of Misoprostol for Medical Treatment of Missed Miscarriage in Clinical Practice: A Single Saudi Center Experience.International journal of women's health · 2026Article
- Article
- Insights into Reproductive Immunology and Placental Pathology.International journal of molecular sciences · 2024Article
- Article
- Coagulation Status in Women with a History of Missed Abortion.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Article
- Association between the vaginal and uterine microbiota and the risk of early embryonic arrest.Frontiers in microbiology · 2023Article
- Risk factors for missed abortion: retrospective analysis of a single institution's experience.Reproductive biology and endocrinology : RB&E · 2022Article
- Correlation between Serum Vitamin D and Calcium Levels in Missed Miscarriage.Archives of Razi Institute · 2022Article
- How many missed abortions are caused by embryonic chromosomal abnormalities and what are their risk factors?Frontiers in genetics · 2022Article
- Hypofibrinogenemia and miscarriage: report of a first successful pregnancy under fibrinogen substitution and short review of the literature.Archive of clinical cases · 2022Article
- Imbalance of the Gut Microbiota May Be Associated with Missed Abortions: A Perspective Study from a General Hospital of Hunan Province.Journal of immunology research · 2021Article
- The expression and clinical significance of three lncRNAs in patients with a missed abortion.Experimental and therapeutic medicine · 2021Article
- Retrospective analysis of prognostic value of the neutrophil-to-lymphocyte ratio in early miscarriages: A 8-year survey.Medicine · 2020Observational
- Exploring the predictive value of complete blood count inflammatory parameters in early pregnancy for missed abortion.Science progressArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of fertile women with missed abortion dramatically increased in recent years, while very few serum indices have been identified for the diagnosis of missed abortion. The aim of this study was to identify related factors for missed abortion through a retrospective study of serum indices.A total of 795 cases of women with missed abortion and 694 cases of women with normal pregnancy between March 2014 and March 2017 were included in the present study. The diagnosis of missed abortion was based on clinical history, clinical examination, and transvaginal ultrasound findings. The final diagnosis of missed abortion was based on assessment of pregnancy structures (i.e., a gestational sac without fetal heart rate) via transvaginal ultrasound. We evaluated the clinical values of 4 serum indices and their relationship to missed abortion: gamma-glutamyltransferase (GGT), lactate dehydrogenase (LDH), adenosine deaminase (ADA), and fibrinogen (FIB).The serum levels of GGT, ADA, and FIB showed statistically significant differences comparing women who experienced missed abortion with women who had normal pregnancies (controls). Among women with missed abortion, the levels of GGT and ADA were dramatically increased (GGT: P < .0001; ADA: P = .0459), while FIB levels were slightly lower (P = .0084) compared to controls. The LDH levels exhibited a non-significant trend toward lower levels in the missed abortion group (P = .3951). Interestingly, the observed significant increase in serum GTT levels among women with missed abortion was not affected by maternal age.This study found that GTT may be a useful marker which was associated with missed abortion, indicating its potential clinical roles in missed abortion.
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