Trial reportMedicine2018
The influence of high-dose intraoperative remifentanil on postoperative sore throat: a prospective randomized study: A CONSORT compliant article.
Trial report in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03173339 (Influence of Remifentanil on Postoperative Sore Throat in Patients Undergoing General Anesthesia), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of Remifentanil on Postoperative Sore Throat in Patients Undergoing General Anesthesia
Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Postoperative sore throat: a systematic review.Anaesthesia · 2026Pooled it
- Postoperative pain after different doses of remifentanil infusion during anaesthesia: a meta-analysis.BMC anesthesiology · 2024Pooled it
- The effect of cooled endotracheal tubes on postoperative sore throat: a randomized controlled study.Croatian medical journal · 2025Trial
- Influence of two-handed jaw thrust during tracheal intubation on postoperative sore throat: a prospective randomised study.The Journal of international medical research · 2021Trial
- Postoperative Sore Throat After Tracheal Intubation: An Updated Narrative Review and Call for Action.Journal of pain research · 2025Review
- Comparison between I-gelAmerican journal of translational research · 2022Article
- The effect of dexmedetomidine and remifentanil on the postoperative sore throat after thyroidectomy.Medicine · 2020Article
- Laryngeal mask airway reduces incidence of post-operative sore throat after thyroid surgery compared with endotracheal tube: a single-blinded randomized controlled trial.BMC anesthesiology · 2020Article
- Impact of intraoperative remifentanil on postoperative pain and opioid use in thyroid surgery.Journal of surgical oncology · 2019Article
- Remifentanil-Induced Secondary Hyperalgesia Is Not Prevented By Preoperative Acetazolamide Administration In Patients Undergoing Total Thyroidectomy: A Randomized Controlled Trial.Journal of pain research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndotracheal intubation for general anesthesia causes postoperative sore throat (POST). This study is designed to evaluate the effect of high-dose remifentanil on the incidence of POST in patients after general anesthesia.
methodsNinety-two patients scheduled for orthopedic lower extremity surgery under general anesthesia were randomly assigned into 1 of 2 groups. In the high-dose remifentanil (HR) group (n = 46), remifentanil was infused at a rate of 0.25 μg/kg/min and subsequently increased or decreased by 0.05 μg/kg/min per clinical demand. In the low-dose remifentanil (LR) group (n = 46), remifentanil was infused at a rate of 0.05 μg/kg/min. The incidence of POST was monitored at 0, 2, 4, and 24 hours postoperatively. Complications regarding opioids were compared between groups.
resultsThe overall incidence of POST was higher in the HR group compared with that in the LR group [33 (72%) vs 18 (39%), P = .022]. The incidence of POST at 0, 2, and 24 hours after surgery was higher in the HR group compared with that in the LR group (P < .001, P = .001, and P = .001, respectively). The incidence of postoperative nausea, vomiting, drowsiness, and headache was similar between the groups. The incidence of postoperative shivering was higher in the HR group than in the LR group [10 (22%) vs 2 (4%), difference 17%, 95% CI 2%-33%, P = .027].
conclusionA relatively large dose of intraoperative remifentanil increased the incidence of POST in patients for orthopedic surgery under general anesthesia.
trial registrationClinicaltrials.gov Identifier: NCT03173339.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.