SynthesisMedicine2018
The prognostic value of C-reactive protein to albumin ratio in patients with lung cancer.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic value of albumin-bilirubin grade in lung cancer: a meta-analysis.Journal of cardiothoracic surgery · 2024Pooled it
- Prognostic value of preoperative mGPS, CAR, and NLR in patients undergoing resection for non-small cell lung cancer.Biomolecules & biomedicine · 2026Article
- Elevated C-reactive protein-to-albumin ratio as an independent prognostic marker for mortality in sepsis: a multicenter cohort study.Frontiers in cellular and infection microbiology · 2026Article
- Serum C-reactive protein to albumin ratio as a reliable marker of diabetic neuropathy in type 2 diabetes mellitus.Biomolecules & biomedicine · 2024Article
- Predictive value of serum albumin levels on cancer survival: a prospective cohort study.Frontiers in oncology · 2024Article
- Article
- Nutritional Status Is Associated With Survival Following Spinal Surgery in Patients With Metastatic Spinal Tumors.Cureus · 2023Article
- C-reactive protein and lactate dehydrogenase serum levels potentially predict the response to checkpoint inhibitors in patients with advanced non-small cell lung cancer.Journal of thoracic disease · 2023Article
- Role of C-Reactive Protein in Predicting the Severity and Response of Immune-Mediated Diarrhea and Colitis in Patients with Cancer.Journal of Cancer · 2023Article
- Correlation between C-reactive protein/albumin ratio and prognosis in patients with lung adenocarcinoma.The Journal of international medical research · 2022Article
- Relationship between disease impact scores and C-reactive protein/albumin ratio in patients with psoriatic arthritis.Croatian medical journal · 2022Article
- What Are the Most Effective Factors in Determining Future Exacerbations, Morbidity Weight, and Mortality in Patients with COPD Attack?Medicina (Kaunas, Lithuania) · 2022Article
- C-Reactive Protein-to-Albumin Ratio as an Early Biomarker to Identify Sepsis in Neonates with Pneumonia.Mediators of inflammation · 2022Article
- Predictive value of postoperative C-reactive protein-to-albumin ratio in anastomotic leakage after esophagectomy.Journal of cardiothoracic surgery · 2021Article
- Modified Glasgow Prognostic Score is predictive of prognosis for non-small cell lung cancer patients treated with stereotactic body radiation therapy: a retrospective study.Journal of radiation research · 2021Article
- Association between the C-reactive protein/albumin ratio and prognosis in patients with oral squamous cell carcinoma.Scientific reports · 2021Article
- Review
- Predictive Value of C-Reactive Protein-to-Albumin Ratio for Neonatal Sepsis.Journal of inflammation research · 2021Article
- C-Reactive Protein-to-Albumin Ratio Predicts Sepsis and Prognosis in Patients with Severe Burn Injury.Mediators of inflammation · 2021Article
- A multi-parametric prognostic model based on clinical features and serological markers predicts overall survival in non-small cell lung cancer patients with chronic hepatitis B viral infection.Cancer cell international · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo perform a meta-analysis of retrospective studies exploring the association of C-reactive protein to albumin (CAR) with overall survival (OS) in patients with lung cancer.
methodsRelevant studies were enrolled by searching databases of PubMed, Cochrane Library, Web of Science, and Embase were searched until July 16, 2017. We combined the hazard ratios (HRs) and 95% confidence intervals (CIs) to assess the correlation between CAR and OS in patients with lung cancer
results: Four studies involving 1257 participants from several countries were involved in the meta-analysis. In a pooled analysis of all studies, elevated CAR predicted poor OS (HR: 2.13; 95% CI: 1.52-2.97; P < .05). Subgroup analysis showed that high level of CAR predicted poor OS in patients with lung cancer though multivariate analyses on 1092 participants (HR: 1.63; 95% CI: 1.24-2.51; P < .001) and the heterogeneity decreased to 45.4%. Moreover, a similar trend was observed in patients receiving surgery (HR: 2.64; 95% CI: 2.08-3.35; P < .001) and chemotherapy (HR: 1.75; 95% CI: 1.93-2.57; P = .004). And the HRs for patients receiving surgery was moderately higher than that for patients receiving chemotherapy.
conclusionOur findings indicate that CAR may have a prognostic value in lung cancer as we detected a significant association between elevated CAR and poorer OS. However, further studies are warranted to draw firm conclusions.
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